SONNEVELD, P., Roman HÁJEK, A NAGLER, A SPENCER, J BLADÉ, T ROBAK, SH ZHUANG, JL HAROUSSEAU and R ORLOWSKI. Combined pegylated liposomal doxorubicin and bortezomib is highly effective in patients with recurrent or refractory multiple myeloma who received prior thalidomide/lenalidomide therapy. Cancer. United States: Wiley, 2008, vol. 112, No 7, p. 1529-1537. ISSN 0008-543X.
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Basic information
Original name Combined pegylated liposomal doxorubicin and bortezomib is highly effective in patients with recurrent or refractory multiple myeloma who received prior thalidomide/lenalidomide therapy.
Name in Czech Kombinace liposomálního doxorubicinu a bortezomibu je efektivnější u pacientů s refrakterním mnohočetným myelomem předléčených thlaidomidem/lenalidomidem
Authors SONNEVELD, P., Roman HÁJEK, A NAGLER, A SPENCER, J BLADÉ, T ROBAK, SH ZHUANG, JL HAROUSSEAU and R ORLOWSKI.
Edition Cancer, United States, Wiley, 2008, 0008-543X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 5.238
Organization unit Faculty of Medicine
UT WoS 000254317300013
Keywords (in Czech) mnohočetný myelom;doxorubicin;bortezomib
Keywords in English multiple myeloma;doxorubicin;bortezomib
Tags bortezomib, doxorubicin, multiple myeloma
Tags International impact, Reviewed
Changed by Changed by: Ing. Gabriela Petrovičová, učo 239322. Changed: 22/6/2009 10:18.
Abstract
Recently, the authors reported improved time to disease progression (TTP) with a combination of pegylated liposomal doxorubicin (PLD) and bortezomib compared with bortezomib alone in a phase 3 randomized trial in patients with recurrent/refractory multiple myeloma. (MM). In the current analysis, they determined 1) the efficacy of PLD plus bortezomib versus bortezomib alone in patients with MM who had failed on prior thalidomide/lenalidomide (immunomodulatory drug [IMiD]) treatment and 2) the efficacy and safety profile of PLD plus bortezomib in IMiD-exposed and IMiD-naive patients.
Abstract (in Czech)
Autoři článku popisují výsledky studie, v níž byl pacientům s mnohočetným myelomem podáván bortezomib v kombinaci s liposomálním doxorubicinem.
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