| NĚMEC, PETR, Monika PÁVKOVÁ GOLDBERGOVÁ, Marie ŠTOURAČOVÁ, Anna VAŠKŮ and Miroslav SOUČEK. Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population. Clin Rheumatol. London: Springer, 2008, vol. 27, No 1, p. 59-65. ISSN 0770-3198. |
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@article{817737,
author = {Němec, PETR and Pávková Goldbergová, Monika and Štouračová, Marie and Vašků, Anna and Souček, Miroslav},
article_location = {London},
article_number = {1},
keywords = {TNF rheumatoid arthritis severity},
language = {eng},
issn = {0770-3198},
journal = {Clin Rheumatol},
title = {Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population},
volume = {27},
year = {2008}
}
TY - JOUR
ID - 817737
AU - Němec, PETR - Pávková Goldbergová, Monika - Štouračová, Marie - Vašků, Anna - Souček, Miroslav
PY - 2008
TI - Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population
JF - Clin Rheumatol
VL - 27
IS - 1
SP - 59-65
EP - 59-65
PB - Springer
SN - 07703198
KW - TNF rheumatoid arthritis severity
N2 - Rheumatoid arthritis (RA) is a model of multigenic inflammatory disorder in which tumor necrosis factor-alpha (TNF-alpha) plays an important role. Genetic factors may be implicated in the susceptibility to disease initiation as well as in severity of disease course. Elevated levels of TNF-alpha in the plasma and synovial fluid from RA patients may be associated with polymorphisms in the promoter region of the TNF-alpha gene. The aim of this study was to elucidate putative association between the -308 G/A polymorphism in the promoter region of the TNF-alpha gene and susceptibility to onset and severity of RA. A total of 130 RA patients and a control group of 150 healthy subjects with similar age and sex distribution were available for the study. All patients fulfilled the American College of Rheumatology revised criteria for RA. RA patients had a disease duration of at least 2 years. Radiographs of both hands of all RA patients were scored with the Steinbrocker method. There were 15 patients of stage I (nonerosive form) of RA and 114 patients of stages II-IV (erosive form). To assess the RA patient's functional ability, the Health Assessment Questionnaire (HAQ) was used. The -308 G/A promoter polymorphism of the TNF-alpha gene was detected by polymerase chain reaction and restriction fragment length polymorphism analysis. No differences in genotype distribution and allelic frequences of -308 G/A TNF-alpha promoter polymorphism have been found between RA patients and the control group. Significant differences have been observed within the RA group divided according to the radiographic progression of disease based on the Steinbrocker radiographic score and functional ability (HAQ). These results suggest an association of the -308 G/A polymorphism of the TNF-alpha gene with the severity of RA.
ER -
NĚMEC, PETR, Monika PÁVKOVÁ GOLDBERGOVÁ, Marie ŠTOURAČOVÁ, Anna VAŠKŮ and Miroslav SOUČEK. Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population. \textit{Clin Rheumatol}. London: Springer, 2008, vol.~27, No~1, p.~59-65. ISSN~0770-3198.
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