| KREJČÍ, Pavel, Lisa SALAZAR, Tamara A. KASHIWADA, Katarína CHLEBOVÁ, Alena SALAŠOVÁ, Leslie Michels THOMPSON, Vítězslav BRYJA, Alois KOZUBÍK and William R. WILCOX. Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage. PLoS ONE. 2008, vol. 3, No 12, p. 72-81, 8 pp. ISSN 1932-6203. |
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@article{818205,
author = {Krejčí, Pavel and Salazar, Lisa and Kashiwada, Tamara A. and Chlebová, Katarína and Salašová, Alena and Thompson, Leslie Michels and Bryja, Vítězslav and Kozubík, Alois and Wilcox, William R.},
article_number = {12},
keywords = {FGFR3; STAT1; activation; skeletal dysplasia},
language = {eng},
issn = {1932-6203},
journal = {PLoS ONE.},
title = {Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage},
volume = {3},
year = {2008}
}
TY - JOUR
ID - 818205
AU - Krejčí, Pavel - Salazar, Lisa - Kashiwada, Tamara A. - Chlebová, Katarína - Salašová, Alena - Thompson, Leslie Michels - Bryja, Vítězslav - Kozubík, Alois - Wilcox, William R.
PY - 2008
TI - Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage
JF - PLoS ONE.
VL - 3
IS - 12
SP - 72-81
EP - 72-81
SN - 19326203
KW - FGFR3
KW - STAT1
KW - activation
KW - skeletal dysplasia
N2 - Article analyses activation of STAT1 by the six different FGFR3 mutants associated with skeletal dysplasia. We report that only the K650E and K650M mutants activate STAT1. As these mutants represent only a mionority of patients suffering from FGFR3-related skeletal dysplasia, it appears that STAT1 might not be the major intermediate of FGFR3 signaling in cartilage.
ER -
KREJČÍ, Pavel, Lisa SALAZAR, Tamara A. KASHIWADA, Katarína CHLEBOVÁ, Alena SALAŠOVÁ, Leslie Michels THOMPSON, Vítězslav BRYJA, Alois KOZUBÍK and William R. WILCOX. Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage. \textit{PLoS ONE.}. 2008, vol.~3, No~12, p.~72-81, 8 pp. ISSN~1932-6203.
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