Alternation of retinoic acid induced neural differentiation of
P19 embryonal carcinoma cells by reduction of reactive oxygen
species intracellular production

J 2008

Alternation of retinoic acid induced neural differentiation of P19 embryonal carcinoma cells by reduction of reactive oxygen species intracellular production

KONOPKA, Roman, Lukáš KUBALA, Antonín LOJEK and Jiří PACHERNÍK

Basic information

Original name

Alternation of retinoic acid induced neural differentiation of P19 embryonal carcinoma cells by reduction of reactive oxygen species intracellular production

Authors

KONOPKA, Roman (203 Czech Republic, belonging to the institution), Lukáš KUBALA (203 Czech Republic, guarantor, belonging to the institution), Antonín LOJEK (203 Czech Republic, belonging to the institution) and Jiří PACHERNÍK (203 Czech Republic, belonging to the institution)

Edition

NEUROENDOCRINOLOGY LETTERS, 2008 Oct;29(5):770-4, 2008, 0172-780X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Sweden

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.359

RIV identification code

RIV/00216224:14310/08:00049587

Organization unit

Faculty of Science

UT WoS

000261553200033

Keywords in English

embryonal carcinoma cells; neural differentiation; redox status; antioxidants

Abstract

V originále

Intracellularly generated reactive oxygen species (ROS) are thought to modulate redox sensitive signaling pathways and thus regulate cell physiology including proliferation and differentiation. However, the role of ROS in neuronal differentiation of embryonic pluripotent cells is unknown. For this reason, the modification of retinoic acid (RA) induced neuronal differentiation of mouse embryonal carcinoma cells P19 by selected ROS scavengers and flavoprotein inhibitor was evaluated.

Links

GP524/03/P171, research and development project

Name: Mechanismy řídící neurální diferenciaci myších embryonálních kmenových buněk in vitro

Investor: Czech Science Foundation

Citovat

KONOPKA, Roman, Lukáš KUBALA, Antonín LOJEK and Jiří PACHERNÍK. Alternation of retinoic acid induced neural differentiation of P19 embryonal carcinoma cells by reduction of reactive oxygen species intracellular production. NEUROENDOCRINOLOGY LETTERS. 2008 Oct;29(5):770-4, 2008, vol. 29, No 5, p. 770-774. ISSN 0172-780X.

@article{819204,
   author = {Konopka, Roman and Kubala, Lukáš and Lojek, Antonín and Pacherník, Jiří},
   article_number = {5},
   keywords = {embryonal carcinoma cells; neural differentiation; redox status; antioxidants},
   language = {eng},
   issn = {0172-780X},
   journal = {NEUROENDOCRINOLOGY LETTERS},
   title = {Alternation of retinoic acid induced neural differentiation of P19 embryonal carcinoma cells by reduction of reactive oxygen species intracellular production},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/18987612?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum},
   volume = {29},
   year = {2008}
}

TY  - JOUR
ID  - 819204
AU  - Konopka, Roman - Kubala, Lukáš - Lojek, Antonín - Pacherník, Jiří
PY  - 2008
TI  - Alternation of retinoic acid induced neural differentiation of P19 embryonal carcinoma cells by reduction of reactive oxygen species intracellular production
JF  - NEUROENDOCRINOLOGY LETTERS
VL  - 29
IS  - 5
SP  - 770-774
EP  - 770-774
PB  - 2008 Oct;29(5):770-4
SN  - 0172780X
KW  - embryonal carcinoma cells
KW  - neural differentiation
KW  - redox status
KW  - antioxidants
UR  - http://www.ncbi.nlm.nih.gov/pubmed/18987612?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
L2  - http://www.ncbi.nlm.nih.gov/pubmed/18987612?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
N2  - Intracellularly generated reactive oxygen species (ROS) are thought to modulate redox sensitive signaling pathways and thus regulate cell physiology including proliferation and differentiation. However, the role of ROS in neuronal differentiation of embryonic pluripotent cells is unknown. For this reason, the modification of retinoic acid (RA) induced neuronal differentiation of mouse embryonal carcinoma cells P19 by selected ROS scavengers and flavoprotein inhibitor was evaluated.
ER  -

KONOPKA, Roman, Lukáš KUBALA, Antonín LOJEK and Jiří PACHERNÍK. Alternation of retinoic acid induced neural differentiation of P19 embryonal carcinoma cells by reduction of reactive oxygen species intracellular production. \textit{NEUROENDOCRINOLOGY LETTERS}. 2008 Oct;29(5):770-4, 2008, vol.~29, No~5, p.~770-774. ISSN~0172-780X.

Detailed Information on Publication Record