Detailed Information on Publication Record
2008
Animal behavioural models of depression
ŠULCOVÁ, Alexandra and Jana PISTOVČÁKOVÁBasic information
Original name
Animal behavioural models of depression
Name in Czech
Zvířecí behaviorální modely deprese
Authors
Edition
The International Journal of Neuropsychopharmacology, Cambridge, U.K. Cambridge University Press, 2008, 1461-1457
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 4.378
Organization unit
Faculty of Medicine
UT WoS
000258855500298
Keywords in English
animal; models; depression; antidepressants
Tags
Tags
International impact, Reviewed
Změněno: 29/6/2009 09:55, prof. MUDr. Alexandra Šulcová, CSc.
V originále
The original results presented: a) At the doses used none of drugs tested for their potential antidepressant-like effects (e.g. felbamate, tiagabine, sertindole, amisulpride) changed locomotor behaviour of sham-operated rats, however they inhibited locomotor hyperactivity in the open field test in OB rats. b) Compared to control individuals the group-housed mice repeatedly defeated on interaction with aggressive singly-housed male mouse exhibit significantly higher depression of ambulation in the open field test. This was normalized by clinically proven (e.g. citalopram, valproate) as well as potential antidepressants (e.g. felbamate, rimonabant).
In Czech
Preseetovány originiální výsledky testování potenciálních antidepresiv ve zvířecích modelech: a) olfaktorické bulbektomie (felbamat, tiagabin, sertindol, amisulprid) a b) opakované sociální porážky (felbamat, rimonabant).
Links
| MSM0021622404, plan (intention) |
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