J 2008

Animal behavioural models of depression

ŠULCOVÁ, Alexandra and Jana PISTOVČÁKOVÁ

Basic information

Original name

Animal behavioural models of depression

Name in Czech

Zvířecí behaviorální modely deprese

Edition

The International Journal of Neuropsychopharmacology, Cambridge, U.K. Cambridge University Press, 2008, 1461-1457

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.378

Organization unit

Faculty of Medicine

UT WoS

000258855500298

Keywords in English

animal; models; depression; antidepressants

Tags

International impact, Reviewed
Změněno: 29/6/2009 09:55, prof. MUDr. Alexandra Šulcová, CSc.

Abstract

V originále

The original results presented: a) At the doses used none of drugs tested for their potential antidepressant-like effects (e.g. felbamate, tiagabine, sertindole, amisulpride) changed locomotor behaviour of sham-operated rats, however they inhibited locomotor hyperactivity in the open field test in OB rats. b) Compared to control individuals the group-housed mice repeatedly defeated on interaction with aggressive singly-housed male mouse exhibit significantly higher depression of ambulation in the open field test. This was normalized by clinically proven (e.g. citalopram, valproate) as well as potential antidepressants (e.g. felbamate, rimonabant).

In Czech

Preseetovány originiální výsledky testování potenciálních antidepresiv ve zvířecích modelech: a) olfaktorické bulbektomie (felbamat, tiagabin, sertindol, amisulprid) a b) opakované sociální porážky (felbamat, rimonabant).

Links

MSM0021622404, plan (intention)
Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.