| ANDERSSON, Therese, Erik SÖDERSTEN, Joshua DUCKWORTH K., Anna CASCANTE, Nicolas FRITZ, Paola SACCHETTI, Igor ČERVENKA, Vítězslav BRYJA and Ola HERMANSON. CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells. Journal of Biological Chemistry. 2009, vol. 284, No 6, 10 pp. ISSN 0021-9258. |
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@article{819430,
author = {Andersson, Therese and Södersten, Erik and Duckworth K., Joshua and Cascante, Anna and Fritz, Nicolas and Sacchetti, Paola and Červenka, Igor and Bryja, Vítězslav and Hermanson, Ola},
article_number = {6},
keywords = {Wnt signalling; CXXC5; neural stem cells},
language = {eng},
issn = {0021-9258},
journal = {Journal of Biological Chemistry},
title = {CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells},
volume = {284},
year = {2009}
}
TY - JOUR
ID - 819430
AU - Andersson, Therese - Södersten, Erik - Duckworth K., Joshua - Cascante, Anna - Fritz, Nicolas - Sacchetti, Paola - Červenka, Igor - Bryja, Vítězslav - Hermanson, Ola
PY - 2009
TI - CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells
JF - Journal of Biological Chemistry
VL - 284
IS - 6
SN - 00219258
KW - Wnt signalling
KW - CXXC5
KW - neural stem cells
N2 - In a screen designed to identify novel targets of BMP4 signaling in telencephalic neural stem cells, we found that the levels of the previously uncharacterized factor CXXC5 were reproducibly up-regulated after BMP4 stimulation. We demonstrate that CXXC5 can interact with the Wnt-signaling intermediate Dishevelled and attenuate Wnt signalling. We conclude that CXXC5 is a BMP4-induced inhibitor of Wnt signaling in neural progenitors.
ER -
ANDERSSON, Therese, Erik SÖDERSTEN, Joshua DUCKWORTH K., Anna CASCANTE, Nicolas FRITZ, Paola SACCHETTI, Igor ČERVENKA, Vítězslav BRYJA and Ola HERMANSON. CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells. \textit{Journal of Biological Chemistry}. 2009, vol.~284, No~6, 10 pp. ISSN~0021-9258.
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