BRYJA, Vítězslav, Emma R. ANDERSSON, Alexandra SCHAMBONY, Milan ESNER, Lenka BRYJOVÁ, Kristin K. BIRIS, Anita C. HALL, Bianca KRAFT, Lukáš ČAJÁNEK, Terry P. YAMAGUCHI, Margaret BUCKINGHAM and Ernest ARENAS. The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo. : Molecular Biology of the Cell. 2008, vol. 20, No 3, 13 pp. ISSN 1059-1524.
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Basic information
Original name The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo.
Name in Czech Extracelulární část proteinu Lrp5/6 inhibuje nekanonickou Wnt dráhu in vivo.
Authors BRYJA, Vítězslav (203 Czech Republic, guarantor, belonging to the institution), Emma R. ANDERSSON (752 Sweden), Alexandra SCHAMBONY (276 Germany), Milan ESNER (203 Czech Republic), Lenka BRYJOVÁ (203 Czech Republic), Kristin K. BIRIS (840 United States of America), Anita C. HALL (826 United Kingdom of Great Britain and Northern Ireland), Bianca KRAFT (276 Germany), Lukáš ČAJÁNEK (203 Czech Republic), Terry P. YAMAGUCHI (124 Canada), Margaret BUCKINGHAM (826 United Kingdom of Great Britain and Northern Ireland) and Ernest ARENAS (724 Spain).
Edition : Molecular Biology of the Cell, 2008, 1059-1524.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 5.558
RIV identification code RIV/00216224:14310/08:00024446
Organization unit Faculty of Science
UT WoS 000263031900017
Keywords in English non-canonical Wnt signalling; Lrp5/6; mouse; Xenopus
Tags Lrp5/6, mouse, Non-canonical Wnt signalling, Xenopus
Changed by Changed by: prof. Mgr. Vítězslav Bryja, Ph.D., učo 11088. Changed: 26/3/2012 14:22.
Abstract
Lrp5/6 are crucial coreceptors for Wnt/beta-catenin signaling, a pathway biochemically distinct from noncanonical Wnt signaling pathways. Here, we examined the possible participation of Lrp5/6 in noncanonical Wnt signaling using biochemical approach, and mouse and Xenopus in vivo models. We provide evidence that the extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt signaling during Xenopus and mouse development in vivo.
Abstract (in Czech)
Lrp5/6 jsou klíčové koreceptory pro Wnt/beta-kateninovou dráhu, která je biochemicky odlišná od tzv. nekanonických Wnt drah. V tomto článku, jsme zkoumali význam Lrp5/6 v nekanonické Wnt dráze s využitím biochemických přístupů a in vivo v embryonálním vývoji myši a drápatky. Naše práce ukazuje, že extracelulární část Lrp5/6 se chová jako fyziologicky relevantní inhibitor nekanonické Wnt dráhy v průběhu embryonálního vývoje.
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MSM0021622430, plan (intention)Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie
Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
1658, interní kód MUName: EMBO Young Investigator Programme (Acronym: EMBO)
Investor: EMBO (European Molecular Biology Organization), EMBO Young Investigator Programme
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