Detailed Information on Publication Record
2008
MICROCHIMERISM - LOOK INTO THE INCIPIENT AML RELAPSE?
HORKÝ, Ondřej, Jiří MAYER, Lenka KABLÁSKOVÁ, Marek BORSKÝ, Dana OHLÍDALOVÁ et. al.Basic information
Original name
MICROCHIMERISM - LOOK INTO THE INCIPIENT AML RELAPSE?
Name in Czech
Mikrochimérizmus-vhled do počínajícího relapsu AML?
Authors
HORKÝ, Ondřej (203 Czech Republic, guarantor, belonging to the institution), Jiří MAYER (203 Czech Republic, belonging to the institution), Lenka KABLÁSKOVÁ (203 Czech Republic), Marek BORSKÝ (203 Czech Republic), Dana OHLÍDALOVÁ (203 Czech Republic), Marta KREJČÍ (203 Czech Republic, belonging to the institution) and Dana DVOŘÁKOVÁ (203 Czech Republic, belonging to the institution)
Edition
Haematologica-the hematology journal, 2008
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Italy
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 5.978
RIV identification code
RIV/00216224:14110/08:00027839
Organization unit
Faculty of Medicine
ISSN
UT WoS
000263430201557
Keywords in English
mikrochimerism; relapse; prediction
Tags
Tags
International impact, Reviewed
Změněno: 9/5/2013 16:50, Mgr. Dana Hrabcová
V originále
The reoccurrence or increase in autologous hematopoiesis after an allogeneic hematopoietic cell transplantation (allo-HCT) has been linked with incipient leukemia relapse, however, clear definition of such "emergency" in terms of microchimerism has not been defined yet. Aims Since the usual minimal residual disease (MRD) analysis is more sensitive than conventional chimerism analysis and MRD-guided intervention is routinely used after transplantation, here we wanted to explore if more sensitive chimerism analysis (microchimerism) could be used for earlier detection of imminent relapse. Methods We compared conventional polymerase chain reaction (PCR) of minisatellite, microsatellite, or sex specific regions with following fragment analysis (FA) (limit of quantification ~1%), with real-time quantitative PCR (RQ-PCR) of insertion/deletion and sex polymorphism (limit of quantification ~0.1%).
In Czech
Znovuobjevení se autologní krvetvorby po alogenní transplantaci hematopoetických kmenových buněk je spojováno s počínajícím relapsem základní choroby. Srovnání úspěšnosti predikce molekulárního relapsu na základě sledování minimální reziduální choroby a mikrochimérismu.
Links
| MSM0021622430, plan (intention) |
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