IN VITRO ASSESSMENT OF INTERACTION OF HUMIC SUBSTANCES WITH 2,3,7,8-TCDD

BITTNER, Michal, Klára HILSCHEROVÁ and John P. GIESY. IN VITRO ASSESSMENT OF INTERACTION OF HUMIC SUBSTANCES WITH 2,3,7,8-TCDD. In 28th International Symposium on Halogentaed Persistent Pollutants. 2008.

Basic information

• Original name: IN VITRO ASSESSMENT OF INTERACTION OF HUMIC SUBSTANCES WITH 2,3,7,8-TCDD
• Name in Czech: In vitro zhodnocení interakce huminových látek s TCDD
• Authors: BITTNER, Michal (203 Czech Republic, guarantor, belonging to the institution), Klára HILSCHEROVÁ (203 Czech Republic, belonging to the institution) and John P. GIESY (840 United States of America).
• Edition: 28th International Symposium on Halogentaed Persistent Pollutants, 2008.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 10511 Environmental sciences
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/08:00025285
• Organization unit: Faculty of Science
• Keywords (in Czech): huminové látky, Ah receptor, dioxin, interakce
• Keywords in English: humic substances; Ah receptor; dioxin; interaction; agonist
• Tags: agonist, Ah Receptor, dioxin, Humic substances, interaction

Abstract

Humic substances (HS) are ubiquitous natural products of decomposition of dead organic matter. In our previous in vitro study, we have described interaction of HS with AhR5, which has been also confirmed in vivo6. In this contribution, we summarize our new findings on interaction of both AhR-active and -inactive HS with 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD). We have observed decrease of TCDD-caused AhR-mediated effect at very high amounts of both TCDD and AhR-active HS. On the other hand, AhR-mediated effect was rather additive at lower concentrations of both TCDD and AhR-active HS. The possible mechanisms are discussed.

Abstract (in Czech)

viz angl.

Links

• GP525/08/P464, research and development project: Name: Interakce huminových látek a UV-VIS záření s dioxinově aktivními environmentálními polutanty

Investor: Czech Science Foundation, Interaction of humic substances and UV-VIS irradiation with dioxin-like environmental pollutants

• MSM0021622412, plan (intention): Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)

Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)