Interference with hormonal signaling and dioxin-like activity elicited by pollutants in particulate and gaseous air fractions

NOVÁK, Jiří, Veronika JÁLOVÁ, JP GIESY and Klára HILSCHEROVÁ. Interference with hormonal signaling and dioxin-like activity elicited by pollutants in particulate and gaseous air fractions. Environment International. Amsterdam, The Netherlands: Elsevier, 2009, vol. 35, No 1, p. 43 – 49. ISSN 0160-4120.

Basic information

• Original name: Interference with hormonal signaling and dioxin-like activity elicited by pollutants in particulate and gaseous air fractions
• Name in Czech: Potenciál narušení hormonální regulace a aktivita dioxinového typu u polutantů z pevné a plynné frakce ovzduší
• Authors: NOVÁK, Jiří (203 Czech Republic), Veronika JÁLOVÁ (203 Czech Republic), JP GIESY (840 United States of America) and Klára HILSCHEROVÁ (203 Czech Republic, guarantor).
• Edition: Environment International, Amsterdam, The Netherlands, Elsevier, 2009, 0160-4120.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10511 Environmental sciences
• Country of publisher: Netherlands
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 4.786
• RIV identification code: RIV/00216224:14310/09:00029254
• Organization unit: Faculty of Science
• UT WoS: 000262218500007
• Keywords (in Czech): ovzduší; endocrinní disrupce; toxicita dioxinového typu; antiestrogenní; antiandrogenní
• Keywords in English: air; endocrine disruption; dioxin-like toxicity; antiestrogenic; antiandrogenic
• Tags: Air, antiandrogenic, antiestrogenic, dioxin-like toxicity, endocrine disruption
• Tags: International impact, Reviewed

Abstract

Interference with hormonal signaling and dioxin-like activity elicited by pollutants in particulate and gaseous air fractions. Traditionally, contamination of air has been evaluated primarily by chemical analyses of indicator contaminants and these studies have focused mainly on compounds associated with particulates. Some reports have shown that air contaminants can produce specific biological effects such as toxicity mediated by the aryl hydrocarbon receptor (AhR) or modulation of the endocrine system. This study assessed the dioxin-like toxicity, anti/estrogenicity, anti/androgenicity and anti/retinoic activity of both the particulate and gas phase fractions of air in two regions with different types of pollution sources and a background locality situated in an agricultural area of Central Europe.

Abstract (in Czech)

Studie dokumentuje potenciál narušení hormonální regulace a aktivity dioxinového typu u polutantů z pevné a plynné frakce ovzduší u vzorků ze dvou oblastí s různým typem zdrojů znečištění. Studie se zaměřuje na toxicitu dioxinového typu, anti/estrogenitu, anti/androgenitu a anti/retinoidní aktivitu.

Links

• GP525/05/P160, research and development project: Name: In vitro modely pro studium endokrinní disrupce - účinky tradičních a nových typů persistentních organických polutantů

Investor: Czech Science Foundation, In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants

• MSM0021622412, plan (intention): Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)

Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)

• 2B08036, research and development project: Name: Nové molekulárně biologické a biochemické metody pro monitoring estrogenů a dalších chemických endokrinních disruptorů (Acronym: ENVISCREEN)

Investor: Ministry of Education, Youth and Sports of the CR, New molecular biology and biochemical methods to monitor estrogens and other endocrine disruptors in the environment of the C.R.