RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND
HEREDITY IN PSORIASIS PATIENTS

D 2009

RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND HEREDITY IN PSORIASIS PATIENTS

VAŠKŮ, Vladimír, Anna VAŠKŮ, Julie BIENERTOVÁ VAŠKŮ and Veronika SLONKOVÁ

Basic information

Original name

RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND HEREDITY IN PSORIASIS PATIENTS

Name in Czech

Vztah mezi definovanymi polymorfismy v HLA-příbuzných genech a dědičností u psoriázy

Authors

VAŠKŮ, Vladimír, Anna VAŠKŮ, Julie BIENERTOVÁ VAŠKŮ and Veronika SLONKOVÁ

Edition

2009. vyd. Bukurešť, 6th EADV Spring Symposium on Psoriasis, p. 310-310, 1 pp. 2009

Publisher

EADV

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30216 Dermatology and venereal diseases

Country of publisher

Romania

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

Keywords (in Czech)

HLA; psoriáza, polymorfismus; dědičnost, přidružená onemocnění

Keywords in English

HLA; psoriasis; polymorphism; heredity; comorbidity

Abstract

ORIG CZ

V originále

The aim of the study is to associate two DNA polymorphic genotypes in HLA region (TAP1 Ile333Val, TNFa (-238 G/A) and NcoI TNFb with heredity aspects of psoriasis. A total of 209 Czech psoriatic patients, 110 men and 107 women, aged 52+-15, was enrolled in the study. Careful information about all family members affected by psoriasis was collected. The genotypes in three polymorphisms in HLA related region were detected by PCR methods with restriction analyses. We observed significantly lower occurrence of Val333 TAP-1 allele in patients with family history of psoriasis in the1st degree relatives (P=0.04), especially in parents (P=0.04). For TNFa (-238 G/A) polymorphisms, a significant decrease of the A allele was found in patients with psoriasis reported in the 2nd and the 3rd degree relatives (P=0.01). Similarly, allele B1 of NcoI TNFb polymorphism was less frequent in psoriatic patients with psoriasis documented in the 2nd and the 3rd degree relatives (P=0.008). In conclusion, the detail family history of psoriasis enables to specify more exactly existing associations among heredity aspects of psoriasis and variability in candidate genes of the disease.

In Czech

Studie zkoumala vztah mezi definovanou variabilitou v HLA systému a hereditárními charakteristikami u psoriázy na souboru celkem 209 českých pacientů s psoriázou.

Links

MSM 141100002, plan (intention)

Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

Citovat

VAŠKŮ, Vladimír, Anna VAŠKŮ, Julie BIENERTOVÁ VAŠKŮ and Veronika SLONKOVÁ. RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND HEREDITY IN PSORIASIS PATIENTS. In 6th EADV Spring Symposium on Psoriasis. 2009th ed. Bukurešť: EADV, 2009, p. 310-310.

@inproceedings{830609,
   author = {Vašků, Vladimír and Vašků, Anna and Bienertová Vašků, Julie and Slonková, Veronika},
   address = {Bukurešť},
   booktitle = {6th EADV Spring Symposium on Psoriasis},
   edition = {2009},
   keywords = {HLA; psoriasis; polymorphism; heredity; comorbidity},
   language = {eng},
   location = {Bukurešť},
   pages = {310-310},
   publisher = {EADV},
   title = {RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND HEREDITY IN PSORIASIS PATIENTS},
   year = {2009}
}

TY  - JOUR
ID  - 830609
AU  - Vašků, Vladimír - Vašků, Anna - Bienertová Vašků, Julie - Slonková, Veronika
PY  - 2009
TI  - RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND HEREDITY IN PSORIASIS PATIENTS
PB  - EADV
CY  - Bukurešť
KW  - HLA
KW  - psoriasis
KW  - polymorphism
KW  - heredity
KW  - comorbidity
N2  - The aim of the study is to associate two DNA polymorphic genotypes in HLA region (TAP1 Ile333Val, TNFa (-238 G/A) and NcoI TNFb with heredity aspects of psoriasis. A total of 209 Czech psoriatic patients, 110 men and 107 women, aged 52+-15, was enrolled in the study. Careful information about all family members affected by psoriasis was collected. The genotypes in three polymorphisms in HLA related region were detected by PCR methods with restriction analyses. We observed significantly lower occurrence of Val333 TAP-1 allele in patients with family history of psoriasis in the1st degree relatives (P=0.04), especially in parents (P=0.04). For TNFa (-238 G/A) polymorphisms, a significant decrease of the A allele was found in patients with psoriasis reported in the 2nd and the 3rd degree relatives (P=0.01). Similarly, allele B1 of NcoI TNFb polymorphism was less frequent in psoriatic patients with psoriasis documented in the 2nd and the 3rd degree relatives (P=0.008). In conclusion, the detail family history of psoriasis enables to specify more exactly existing associations among heredity aspects of psoriasis and variability in candidate genes of the disease.
ER  -

VAŠKŮ, Vladimír, Anna VAŠKŮ, Julie BIENERTOVÁ VAŠKŮ and Veronika SLONKOVÁ. RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND HEREDITY IN PSORIASIS PATIENTS. In \textit{6th EADV Spring Symposium on Psoriasis}. 2009th ed. Bukurešť: EADV, 2009, p.~310-310.

Detailed Information on Publication Record