BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Dagmar JANSOVÁ, Milena ŠIMURDOVÁ, Marie NOVÁKOVÁ and Jiří ŠIMURDA. Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes. Naunyn-Schmiedebergs Archives of Pharmacology. Německo: Springer, 2009, vol. 380, No 2, p. 125-133. ISSN 0028-1298.
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Basic information
Original name Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes
Name in Czech Vliv antipsychotika perfenazinu na rychlý sodíkový proud a přechodný draslíkový proud u komorových srdečních buněk potkana
Authors BÉBAROVÁ, Markéta (203 Czech Republic, guarantor, belonging to the institution), Peter MATEJOVIČ (703 Slovakia, belonging to the institution), Michal PÁSEK (203 Czech Republic), Dagmar JANSOVÁ (203 Czech Republic), Milena ŠIMURDOVÁ (203 Czech Republic, belonging to the institution), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution) and Jiří ŠIMURDA (203 Czech Republic, belonging to the institution).
Edition Naunyn-Schmiedebergs Archives of Pharmacology, Německo, Springer, 2009, 0028-1298.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.631
RIV identification code RIV/00216224:14110/09:00028492
Organization unit Faculty of Medicine
UT WoS 000266926900004
Keywords in English perphenazine; antipsychotic drug; sodium current; transient outward current; rat ventricular myocytes
Tags antipsychotic drug, Perphenazine, rat ventricular myocytes, sodium current, transient outward current
Tags International impact, Reviewed
Changed by Changed by: doc. Ing. Michal Pásek, Ph.D., učo 46541. Changed: 30/12/2012 17:54.
Abstract
Perphenazine reversibly blocked fast sodium current INa (reducing its amplitude; IC50 = 1.24 microM) and transient outward potassium current Ito (accelerating its apparent inactivation with a slight decrease of its amplitude; IC50 = 38.2 microM, evaluated from changes of the time integral). Both blocks were use- and frequency-dependent at 3.3 Hz. Computer simulations suggest that perphenazine interacts preferentially with INa channels in inactivated states and with Ito channels in both open and open-inactivated states.
Abstract (in Czech)
Perfenazin vratně blokoval rychlý sodíkový proud INa (snižováním jeho amplitudy; IC50 = 1.24 mikroM) a přechodný draslíkový proud z buňky Ito (zrychlovaním jeho zdánlivé inaktivace s lehkým snížením amplitudy; IC50 = 38.2 mikroM, vyhodnoceno ze změn časového integrálu). Obě blokády byly frekvenčně závislé při 3.3 Hz. Počítačové simulace ukázaly, že perfenazin působí na INa kanály zejména přes jejich inaktivované stavy a s Ito kanály jak v otevřeném, tak v otevřeném inaktivovaném stavu.
Links
GA305/04/1385, research and development projectName: Modulační úloha sigma signalizace na elektromechanické vztahy izolovaného kardiomyocytu a srdce
Investor: Czech Science Foundation, Modulatory role of sigma signalling in electromechanical coupling of isolated cardiomyocyte and heart
MSM0021622402, plan (intention)Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
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