BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Dagmar JANSOVÁ, Milena ŠIMURDOVÁ, Marie NOVÁKOVÁ and Jiří ŠIMURDA. Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes. Naunyn-Schmiedebergs Archives of Pharmacology. Německo: Springer, 2009, vol. 380, No 2, p. 125-133. ISSN 0028-1298. |
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@article{831416, author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Jansová, Dagmar and Šimurdová, Milena and Nováková, Marie and Šimurda, Jiří}, article_location = {Německo}, article_number = {2}, keywords = {perphenazine; antipsychotic drug; sodium current; transient outward current; rat ventricular myocytes}, language = {eng}, issn = {0028-1298}, journal = {Naunyn-Schmiedebergs Archives of Pharmacology}, title = {Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes}, volume = {380}, year = {2009} }
TY - JOUR ID - 831416 AU - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Jansová, Dagmar - Šimurdová, Milena - Nováková, Marie - Šimurda, Jiří PY - 2009 TI - Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes JF - Naunyn-Schmiedebergs Archives of Pharmacology VL - 380 IS - 2 SP - 125-133 EP - 125-133 PB - Springer SN - 00281298 KW - perphenazine KW - antipsychotic drug KW - sodium current KW - transient outward current KW - rat ventricular myocytes N2 - Perphenazine reversibly blocked fast sodium current INa (reducing its amplitude; IC50 = 1.24 microM) and transient outward potassium current Ito (accelerating its apparent inactivation with a slight decrease of its amplitude; IC50 = 38.2 microM, evaluated from changes of the time integral). Both blocks were use- and frequency-dependent at 3.3 Hz. Computer simulations suggest that perphenazine interacts preferentially with INa channels in inactivated states and with Ito channels in both open and open-inactivated states. ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Dagmar JANSOVÁ, Milena ŠIMURDOVÁ, Marie NOVÁKOVÁ and Jiří ŠIMURDA. Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes. \textit{Naunyn-Schmiedebergs Archives of Pharmacology}. Německo: Springer, 2009, vol.~380, No~2, p.~125-133. ISSN~0028-1298.
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