| GOERKE, Christiane, Roman PANTŮČEK, Silvia HOLTFRETER, Berit SCHULTE, Manuel ZINK, Dorothee GRUMANN, Barbara M. BRÖKER, Jiří DOŠKAŘ a Christiane WOLZ. Diversity of prophages in dominant Staphylococcus aureus> clonal lineages. Journal of Bacteriology. Washington, D.C.: American Society for Microbiology, roč. 191, č. 11, s. 3462-3468. ISSN 0021-9193. 2009. |
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@article{832297,
author = {Goerke, Christiane and Pantůček, Roman and Holtfreter, Silvia and Schulte, Berit and Zink, Manuel and Grumann, Dorothee and Bröker, Barbara M. and Doškař, Jiří and Wolz, Christiane},
article_location = {Washington, D.C.},
article_number = {11},
keywords = {Staphylococcus aureus; bacteriophages; accessory genome; clonal lineages; lysogeny},
language = {eng},
issn = {0021-9193},
journal = {Journal of Bacteriology},
title = {Diversity of prophages in dominant Staphylococcus aureus> clonal lineages},
url = {http://jb.asm.org/cgi/content/full/191/11/3462},
volume = {191},
year = {2009}
}
TY - JOUR
ID - 832297
AU - Goerke, Christiane - Pantůček, Roman - Holtfreter, Silvia - Schulte, Berit - Zink, Manuel - Grumann, Dorothee - Bröker, Barbara M. - Doškař, Jiří - Wolz, Christiane
PY - 2009
TI - Diversity of prophages in dominant Staphylococcus aureus> clonal lineages
JF - Journal of Bacteriology
VL - 191
IS - 11
SP - 3462-3468
EP - 3462-3468
PB - American Society for Microbiology
SN - 00219193
KW - Staphylococcus aureus
KW - bacteriophages
KW - accessory genome
KW - clonal lineages
KW - lysogeny
UR - http://jb.asm.org/cgi/content/full/191/11/3462
N2 - Temperate bacteriophages play an important role in the pathogenicity of Staphylococcus aureus, for instance, by mediating the horizontal gene transfer of virulence factors. Here we established a classification scheme for staphylococcal prophages of the major Siphoviridae family based on integrase gene polymorphism. Seventy-one published genome sequences of staphylococcal phages were clustered into distinct integrase groups which were related to the chromosomal integration site and to the encoded virulence gene content. Analysis of three marker modules (lysogeny, tail, and lysis) for phage functional units revealed that these phages exhibit different degrees of genome mosaicism. The prevalence of prophages in a representative S. aureus strain collection consisting of 386 isolates of diverse origin was determined. By linking the phage content to dominant S. aureus clonal complexes we could show that the distribution of bacteriophages varied remarkably between lineages, indicating restriction-based barriers. A comparison of colonizing and invasive S. aureus strain populations revealed that hlb-converting phages were significantly more frequent in colonizing strains.
ER -
GOERKE, Christiane, Roman PANTŮČEK, Silvia HOLTFRETER, Berit SCHULTE, Manuel ZINK, Dorothee GRUMANN, Barbara M. BRÖKER, Jiří DOŠKAŘ a Christiane WOLZ. Diversity of prophages in dominant Staphylococcus aureus$>$ clonal lineages. \textit{Journal of Bacteriology}. Washington, D.C.: American Society for Microbiology, roč.~191, č.~11, s.~3462-3468. ISSN~0021-9193. 2009.
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