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@inproceedings{832755,
author = {Bienertová Vašků, Julie and Bienert, Petr and Forejt, Martin and Tomandl, Josef and Vavřina, Martin and Kudělková, Jana and Chmelíková, Monika and Heczková, Kateřina and Piskáčková, Zlata and Kučerová, Lenka and Derflerová Brázdová, Zuzana and Vašků, Anna},
address = {Vídeň, Rakousko},
booktitle = {European Journal of Human Genetics, suppl.},
edition = {209},
keywords = {adipokine; polymorphism; dietary composition; genotype; nutrient},
language = {eng},
location = {Vídeň, Rakousko},
pages = {252-252},
publisher = {European Society of Human Genetics},
title = {Genotypes-by-nutrient associations of common polymorphisms in obesity-related genes within the Czech population},
year = {2009}
}
TY - JOUR
ID - 832755
AU - Bienertová Vašků, Julie - Bienert, Petr - Forejt, Martin - Tomandl, Josef - Vavřina, Martin - Kudělková, Jana - Chmelíková, Monika - Heczková, Kateřina - Piskáčková, Zlata - Kučerová, Lenka - Derflerová Brázdová, Zuzana - Vašků, Anna
PY - 2009
TI - Genotypes-by-nutrient associations of common polymorphisms in obesity-related genes within the Czech population
PB - European Society of Human Genetics
CY - Vídeň, Rakousko
KW - adipokine
KW - polymorphism
KW - dietary composition
KW - genotype
KW - nutrient
N2 - INTRODUCTION: The personal food preferences can either enhance or suppress the development of obesity and the selection and proportion of macronutrients in the diet seems to have a heritable component. In this study, we therefore focused on dietary composition as a specific trait related to obesity and we determined, whether genetic variations in leptin (LEP), leptin receptor (LEPR), ghrelin (GHRL), adiponectin (ADIPOQ), interleukin 6 (IL6), proopiomelanocortin (POMC) and melanocortin-4 receptor (MC4R) underlie specific native food preferences and obesity-realated anthropometric parameters. METHODS: The total of 409 individuals of Czech Caucasian origin were enrolled into this study and the 7-day food records and parallel 7-day records of physical activity were obtained from the study subject as well as anthropometric measurements. In a subset of study subjects, plasma levels of adiponectin, leptin and soluble leptin receptor were measured. RESULTS: Independenty on the BMI of the individuals, common variations in leptin and leptin receptor genes were associated with specific eating patterns, mainly with respect to timing of eating. Diastolic blood pressure was significantly associated with the common variation in the leptin receptor gene as well as with the ratio of soluble leptin receptor and leptin plasma levels. In multivariate analysis, common variations in LEP, LEPR, POMC and MC4R genes expressed an independent prediction role for percentage of body fat. DISCUSSION: To conclude, we report common allelic variants associated with specific feeding behaviour and obesity-related anthropometric traits. Moreover, we identified allelic variants that significantly influence time structure of food intake during the day.
ER -
BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Martin FOREJT, Josef TOMANDL, Martin VAVŘINA, Jana KUDĚLKOVÁ, Monika CHMELÍKOVÁ, Kateřina HECZKOVÁ, Zlata PISKÁČKOVÁ, Lenka KUČEROVÁ, Zuzana DERFLEROVÁ BRÁZDOVÁ and Anna VAŠKŮ. Genotypes-by-nutrient associations of common polymorphisms in obesity-related genes within the Czech population. In \textit{European Journal of Human Genetics, suppl.}. 209th ed. Vídeň, Rakousko: European Society of Human Genetics, 2009, p.~252-252.
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