LEGARTOVÁ, Soňa, Jana KREJČÍ, Andrea HARNIČAROVÁ, Roman HÁJEK, Stanislav KOZUBEK and Eva BÁRTOVÁ. Nuclear topography of the 1q21 genomic region and Mcl-1 protein levels associated with pathophysiology of multiple myeloma. Neoplasma. Slovakia: Slovak Academic Press Ltd., 2009, vol. 56, No 5, p. 404-413. ISSN 0028-2685.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Nuclear topography of the 1q21 genomic region and Mcl-1 protein levels associated with pathophysiology of multiple myeloma
Name in Czech Jaderná topografie úseku 1q21 a hladiny Mcl-1 proteinu spojené s patofyziologií mnohočetného myelomu
Authors LEGARTOVÁ, Soňa (703 Slovakia), Jana KREJČÍ (203 Czech Republic), Andrea HARNIČAROVÁ (703 Slovakia), Roman HÁJEK (203 Czech Republic), Stanislav KOZUBEK (203 Czech Republic) and Eva BÁRTOVÁ (203 Czech Republic, guarantor).
Edition Neoplasma, Slovakia, Slovak Academic Press Ltd. 2009, 0028-2685.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher Slovakia
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.192
RIV identification code RIV/00216224:14310/09:00028495
Organization unit Faculty of Science
UT WoS 000269333200006
Keywords (in Czech) mnohočetný myelom; 1q21; DNA-FISH
Keywords in English multiple myeloma; 1q21; DNA-FISH
Tags 1q21, DNA-FISH, multiple myeloma
Tags International impact, Reviewed
Changed by Changed by: Mgr. Anna Potáčová, Ph.D., učo 44190. Changed: 1/4/2010 17:00.
Abstract
Karyotypic abnormalities seen in MM cells correlate with the disease stage and drug responses. Here, we investigate the nuclear arrangement of the 1q21 region; amplification of this region is an important diagnostic and prognostic marker of MM. We examined the lymphoblastoid cell line CD138- ARH-77, multiple myeloma CD138+ MOLP-8 cells, and the CD138+ bone marrow fraction of patients diagnosed with MM.
Abstract (in Czech)
Abnormality v karyotypu myelomových buněk korelují se stádiem onemocnění a odpovědí na léčbu. Sledovali jsme oblast 1q21; amplifikace tohoto úseku je důležitým diagnostickým a prognostickým markerem u MM. Práce byla provedena na lymfoblastoidní lynii ARH-77, myelomové linii MOLP-8 a na izolovaných plazmatických buňkách pacientů s MM.
PrintDisplayed: 3/5/2024 02:33