J 2009

Fluorescence properties of selected benzo[c]phenantridine and studies of their interaction with CT DNA

URBANOVÁ, Jana, Přemysl LUBAL, Iva SLANINOVÁ, Eva TÁBORSKÁ, Petr TÁBORSKÝ et. al.

Basic information

Original name

Fluorescence properties of selected benzo[c]phenantridine and studies of their interaction with CT DNA

Name in Czech

Fluorescenční vlastnosti vybraných benzofenantridinových alkaloidů a studium jejich interakcí s CT DNA

Authors

URBANOVÁ, Jana (203 Czech Republic), Přemysl LUBAL (203 Czech Republic), Iva SLANINOVÁ (203 Czech Republic), Eva TÁBORSKÁ (203 Czech Republic) and Petr TÁBORSKÝ (203 Czech Republic, guarantor)

Edition

Analytical and Bioanalytical Chemistry, Heidelberg, Springer-Verlag GmbH, 2009, 1618-2642

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.480

RIV identification code

RIV/00216224:14310/09:00029331

Organization unit

Faculty of Science

UT WoS

000266160400010

Keywords (in Czech)

Sanguinarin Chelirubin Sanguirubin Chelilutin Makarpin

Keywords in English

Sanguinarine Chelirubine Sanguirubine Chelilutine Macarpine

Tags

International impact, Reviewed
Změněno: 12/3/2010 09:23, prof. MUDr. Iva Slaninová, Ph.D.

Abstract

ORIG CZ

V originále

The spectral, especially fluorescence properties, of seven selected quaternary benzo[c]phenantridine alkaloids (sanguinarine, chelerythrine, chelirubine, sanguirubine, chelilutine, sanguilutine, and macarpine) were studied in presence and in absence of double-stranded DNA. This study has proved dramatic differences in fluorescence emission of all studied alkaloids in presence of calf thymus DNA in comparison to fluorescence of free alkaloids. The most remarkable are changes in emission spectra of macarpine, chelirubine, and sanguirubine. Association constants (logK) for interaction of all studied alkaloids with CT DNA were calculated.

In Czech

V článku jsou popsány fluorescenční vlastnosti vybraných alkaloidů (Sanguinarin, Chelirubin, Sanguirubin, Chelilutin, Makarpin, Chelerytrin), dále jsou uvedeny asociační konstanty interakce s CT DNA

Links

GA525/08/0819, research and development project
Name: Rostlinné zdroje minoritních benzofenanthridinových alkaloidů a studium interakcí těchto alkaloidů s DNA
Investor: Czech Science Foundation, Plant sources of minor benzofenantridine alkaloids and study of heir interaction with DNA
LC06035, research and development project
Name: Centrum biofyzikální chemie, bioelektrochemie a bioanalýzy. Nové nástroje pro genomiku, proteomiku a biomedicínu.
Investor: Ministry of Education, Youth and Sports of the CR, Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine