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@article{835941, author = {Kopecká, Marie and Gabriel, Miroslav}, article_location = {Basel, Switzerland}, article_number = {4}, keywords = {Yeast;Actin;Microtubules;Paclitaxel;Vincristine;Vinblastine;Methyl benzimidazole2yl carbamate;Thiabendazole; Cytochalasins A B D; Latrunculin A}, language = {eng}, issn = {0009-3157}, journal = {CHEMOTHERAPY}, title = {Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals}, url = {http://www.karger.com/che}, volume = {55}, year = {2009} }
TY - JOUR ID - 835941 AU - Kopecká, Marie - Gabriel, Miroslav PY - 2009 TI - Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals JF - CHEMOTHERAPY VL - 55 IS - 4 SP - 278-286 EP - 278-286 PB - S. KARGER AG, Basel SN - 00093157 KW - Yeast;Actin;Microtubules;Paclitaxel;Vincristine;Vinblastine;Methyl benzimidazole2yl carbamate;Thiabendazole KW - Cytochalasins A B D KW - Latrunculin A UR - http://www.karger.com/che N2 - The cytoskeleton was investigated as a potential target for the inhibition of cell division in Fellomyces fuzhou-ensis related to Cryptococcus neoformans.Vincristine, vinblastine,paclitaxel,methyl benzimidazole-2-yl carbamate (BCM),thiabendazole,cytochalasins A,B,D and latrunculin A were added to cells and investigated.Vincristine, vinblastine, paclitaxel, cytochalasins A,B and D transiently blocked proliferation. BCM disrupted microtubules,inhibited mitosis, but F-actin structures persisted and neck-less conidia originated. Latrunculin disrupted F-actin, cells became spherical,stalks and necks degenerated, microtubules persisted,mitosis,cytokinesis and conidiogenesis were blocked.The combined application of latrunculin and BCM disrupted F-actin and microtubules,inhibited cells became spherical and did not divide.Conclusion: Microtubules and F-actin are effective targets for permanent inhibition of nuclear and cell division and conidiogenesis by BCM and latrunculin A. ER -
KOPECKÁ, Marie and Miroslav GABRIEL. Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals. \textit{CHEMOTHERAPY}. Basel, Switzerland: S. KARGER AG, Basel, 2009, vol.~55, No~4, p.~278-286. ISSN~0009-3157.
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