VESELÝ, Karel, Michal JURAJDA, Rudolf NENUTIL and Marcela VESELÁ. Expression of p53, cyclin D1 and EGFR correlates with histological grade of adult soft tissue sarcomas: a study on tissue microarrays. Neoplasma. Bratislava, Slovensko: AEPress, s.r.o., 2009, vol. 56, No 3, p. 239-244. ISSN 0028-2685. |
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@article{836834, author = {Veselý, Karel and Jurajda, Michal and Nenutil, Rudolf and Veselá, Marcela}, article_location = {Bratislava, Slovensko}, article_number = {3}, keywords = {Immunohistochemistry; soft tissue sarcoma; Ki-67; p53; cyclin D1; EGFR; histological grade; tissue microarrays}, language = {eng}, issn = {0028-2685}, journal = {Neoplasma}, title = {Expression of p53, cyclin D1 and EGFR correlates with histological grade of adult soft tissue sarcomas: a study on tissue microarrays}, volume = {56}, year = {2009} }
TY - JOUR ID - 836834 AU - Veselý, Karel - Jurajda, Michal - Nenutil, Rudolf - Veselá, Marcela PY - 2009 TI - Expression of p53, cyclin D1 and EGFR correlates with histological grade of adult soft tissue sarcomas: a study on tissue microarrays JF - Neoplasma VL - 56 IS - 3 SP - 239-244 EP - 239-244 PB - AEPress, s.r.o. SN - 00282685 KW - Immunohistochemistry KW - soft tissue sarcoma KW - Ki-67 KW - p53 KW - cyclin D1 KW - EGFR KW - histological grade KW - tissue microarrays N2 - Soft tissue sarcomas (STSs) are rare heterogeneous tumors with variable clinical course and outcome. The management of STSs depends upon the accurate histopathological diagnosis and assessing their histological grade. Currently, core needle biopsies are becoming increasingly popular for diagnosing STSs but value of histological grading is limited from this type of specimens. To evaluate the immunohistochemical expression of p53, mdm-2, cyclin D1, p16, nm23, EGFR and Ki-67 labelling index in adult STSs patients and their association with histological grade of STSs, we analysed 101 primary untreated STSs of the limbs and trunk using the tissue microarray technique on formalin-fixed, paraffin-embedded tissue samples. The cases consisted of 15 G1, 28 G2 and 58 G2 sarcomas. Ki-67 labelling index (LI) was calculated from whole block sections for the possibility to select the most proliferative regions. The LI ranged from 1.26 to 75.5% (median 26.7%) and strongly correlated with the mitotic count (p rs for adult patients with STSs and may assist in establishment of the histological grade in STSs. ER -
VESELÝ, Karel, Michal JURAJDA, Rudolf NENUTIL and Marcela VESELÁ. Expression of p53, cyclin D1 and EGFR correlates with histological grade of adult soft tissue sarcomas: a study on tissue microarrays. \textit{Neoplasma}. Bratislava, Slovensko: AEPress, s.r.o., 2009, vol.~56, No~3, p.~239-244. ISSN~0028-2685.
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