THON, Vojtěch, P. HARLE, J. SCHOLMERICH, P. KUKLINEK, Jindřich LOKAJ and RH STRAUB. Lack of dehydroepiandrosterone in type I and II hereditary angioedema and role of danazol in steroid hormone conversion. Allergy. 2007, vol. 62, No 11, p. 1320-1325. ISSN 0105-4538.
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Basic information
Original name Lack of dehydroepiandrosterone in type I and II hereditary angioedema and role of danazol in steroid hormone conversion
Name in Czech Nedostatek dehydroepiandosteronu u pacientů s hereditárním angioedémem a úloha danazolu v konverzi steroidních hormonů
Authors THON, Vojtěch (203 Czech Republic, guarantor, belonging to the institution), P. HARLE (276 Germany), J. SCHOLMERICH (276 Germany), P. KUKLINEK (203 Czech Republic), Jindřich LOKAJ (203 Czech Republic, belonging to the institution) and RH STRAUB (276 Germany).
Edition Allergy, 2007, 0105-4538.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30102 Immunology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 5.014
RIV identification code RIV/00216224:14110/07:00058823
Organization unit Faculty of Medicine
UT WoS 000249953300014
Keywords (in Czech) C1 inhibitor; angioedém; dehydroepiandosteron; danazol
Keywords in English C1 INHIBITOR; C1-INHIBITOR DEFICIENCY; MONONUCLEAR CELLS; BETA ENDORPHIN; EXPRESSION; WOMEN;
Tags BETA ENDORPHIN, C1 inhibitor, C1-INHIBITOR DEFICIENCY, Expression, MONONUCLEAR CELLS, women
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Vojtěch Thon, Ph.D., učo 2483. Changed: 10/4/2013 12:30.
Abstract
Background: Hereditary angioedema (HAE) is successfully treated with danazol, a therapeutic steroid compound. To investigate hormones of the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axis in patients with HAE with and without danazol. Methods: We included 16 patients with type I HAE, nine patients with type II HAE, and 16 healthy subjects. Serum levels of adrenocorticotropic hormone (ACTH), cortisol, androstenedione, dehydroepiandrosterone (DHEA), free testosterone, and 17 beta-oestradiol were measured. Results: Serum levels of ACTH were markedly decreased in patients with type II HAE compared to the other groups (P < 0.001). Serum cortisol was similar between groups but danazol treatment decreased cortisol levels, particularly in women (P = 0.019). Serum levels of DHEA were significantly decreased in all patients with type I and II HAE compared to controls (P < 0.05), which was only partly dependent on prior danazol therapy as patients without danazol had also decreased serum levels of DHEA (P < 0.05). Furthermore, free testosterone serum levels were markedly increased in patients under danazol (P < 0.005) and the ratio of 17 beta-oestradiol/free testosterone was significantly decreased in these patients (P < 0.005). Conclusions: This study demonstrated decreased DHEA in patients with type I and II HAE independent of danazol therapy, which was particularly evident in women. It also demonstrates that danazol induced a marked up-regulation of free testosterone in relation to precursors and downstream 17 beta-oestradiol. In HAE, there seems to be a primary lack of the adrenal androgen DHEA.
Abstract (in Czech)
Nedostatek dehydroepiandosteronu u pacientů s hereditárním angioedémem a úloha danazolu v konverzi steroidních hormonů.
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