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@article{837046,
author = {Horn, J. and Thon, Vojtěch and Bartonkova, D. and Salzer, U. and Warnatz, K. and Schlesier, M. and Peter, HH. and Grimbacher, B.},
article_number = {2},
keywords = {IgG anti IgA antibodies; Common Variable Immunodeficiency (CVID); IgA deficiency},
language = {eng},
issn = {1521-6616},
journal = {CLINICAL IMMUNOLOGY},
title = {Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy},
volume = {122},
year = {2007}
}
TY - JOUR
ID - 837046
AU - Horn, J. - Thon, Vojtěch - Bartonkova, D. - Salzer, U. - Warnatz, K. - Schlesier, M. - Peter, HH. - Grimbacher, B.
PY - 2007
TI - Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy
JF - CLINICAL IMMUNOLOGY
VL - 122
IS - 2
SP - 156-162
EP - 156-162
SN - 15216616
KW - IgG anti IgA antibodies
KW - Common Variable Immunodeficiency (CVID)
KW - IgA deficiency
N2 - Common Variable Immunodeficiency (CVID) patients who are seropositive for anti-IgA antibodies have a predisposition for anaphylactoid reactions to intravenous immunoglobulin replacement therapy (IVIG). Among 88 CVID patients, we identified eight with IgG anti-IgA antibodies (9%). All eight completely tacked IgA (< 0.0009 g/l). Five of them had a history of anaphylactoid reactions to IVIG. However, four of these five patients tolerated subcutaneous immunoglobulin replacement therapy (SCIG). To identify predisposing factors for anti-IgA antibodies and related anaphytactoid reactions, we analyzed the clinical and immunological phenotype of affected patients. All eight IgG anti-IgA-positive patients tacked IgA(+) B cells in peripheral blood. Moreover, CVID patients with retained class-switched CD27(pos) IgM(neg) IgD(neg) memory B cells (Freiburg classification group II) and total IgA deficiency seem to have an increased risk for developing anti-IgA antibodies. In seven of the eight patients, lymphoproliferation was observed (most prominently nodular lymphatic hyperplasia), two had granulomatous disease, and two showed autoimmune phenomena.
ER -
HORN, J., Vojtěch THON, D. BARTONKOVA, U. SALZER, K. WARNATZ, M. SCHLESIER, HH. PETER and B. GRIMBACHER. Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy. \textit{CLINICAL IMMUNOLOGY}. 2007, vol.~122, No~2, p.~156-162. ISSN~1521-6616.
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