Anti-IgA antibodies in Common Variable Immunodeficiency (CVID):
Diagnostic workup and therapeutic strategy

J 2007

Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy

HORN, J., Vojtěch THON, D. BARTONKOVA, U. SALZER, K. WARNATZ et. al.

Basic information

Original name

Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy

Name in Czech

Anti-IgA protilátky u běžné variabilní imunodeficience (CVID): vypracování diagnostické a terapeutické strategie

Authors

HORN, J., Vojtěch THON, D. BARTONKOVA, U. SALZER, K. WARNATZ, M. SCHLESIER, HH. PETER and B. GRIMBACHER

Edition

CLINICAL IMMUNOLOGY, 2007, 1521-6616

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.551

Organization unit

Faculty of Medicine

UT WoS

000243779300006

Keywords (in Czech)

IgG anti IgA protilátky; běžná variabilní imunodeficience (CVID); IgA deficit

Keywords in English

IgG anti IgA antibodies; Common Variable Immunodeficiency (CVID); IgA deficiency

Abstract

ORIG CZ

V originále

Common Variable Immunodeficiency (CVID) patients who are seropositive for anti-IgA antibodies have a predisposition for anaphylactoid reactions to intravenous immunoglobulin replacement therapy (IVIG). Among 88 CVID patients, we identified eight with IgG anti-IgA antibodies (9%). All eight completely tacked IgA (< 0.0009 g/l). Five of them had a history of anaphylactoid reactions to IVIG. However, four of these five patients tolerated subcutaneous immunoglobulin replacement therapy (SCIG). To identify predisposing factors for anti-IgA antibodies and related anaphytactoid reactions, we analyzed the clinical and immunological phenotype of affected patients. All eight IgG anti-IgA-positive patients tacked IgA(+) B cells in peripheral blood. Moreover, CVID patients with retained class-switched CD27(pos) IgM(neg) IgD(neg) memory B cells (Freiburg classification group II) and total IgA deficiency seem to have an increased risk for developing anti-IgA antibodies. In seven of the eight patients, lymphoproliferation was observed (most prominently nodular lymphatic hyperplasia), two had granulomatous disease, and two showed autoimmune phenomena.

In Czech

Anti-IgA protilátky u běžné variabilní imunodeficience (CVID): vypracování diagnostické a terapeutické strategie.

Links

NR9035, research and development project

Name: Specifická protilátková odpověď u pacientů s poruchami imunity

Citovat

HORN, J., Vojtěch THON, D. BARTONKOVA, U. SALZER, K. WARNATZ, M. SCHLESIER, HH. PETER and B. GRIMBACHER. Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy. CLINICAL IMMUNOLOGY. 2007, vol. 122, No 2, p. 156-162. ISSN 1521-6616.

@article{837046,
   author = {Horn, J. and Thon, Vojtěch and Bartonkova, D. and Salzer, U. and Warnatz, K. and Schlesier, M. and Peter, HH. and Grimbacher, B.},
   article_number = {2},
   keywords = {IgG anti IgA antibodies; Common Variable Immunodeficiency (CVID); IgA deficiency},
   language = {eng},
   issn = {1521-6616},
   journal = {CLINICAL IMMUNOLOGY},
   title = {Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy},
   volume = {122},
   year = {2007}
}

TY  - JOUR
ID  - 837046
AU  - Horn, J. - Thon, Vojtěch - Bartonkova, D. - Salzer, U. - Warnatz, K. - Schlesier, M. - Peter, HH. - Grimbacher, B.
PY  - 2007
TI  - Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy
JF  - CLINICAL IMMUNOLOGY
VL  - 122
IS  - 2
SP  - 156-162
EP  - 156-162
SN  - 15216616
KW  - IgG anti IgA antibodies
KW  - Common Variable Immunodeficiency (CVID)
KW  - IgA deficiency
N2  - Common Variable Immunodeficiency (CVID) patients who are seropositive for anti-IgA antibodies have a predisposition for anaphylactoid reactions to intravenous immunoglobulin replacement therapy (IVIG). Among 88 CVID patients, we identified eight with IgG anti-IgA antibodies (9%). All eight completely tacked IgA (< 0.0009 g/l). Five of them had a history of anaphylactoid reactions to IVIG. However, four of these five patients tolerated subcutaneous immunoglobulin replacement therapy (SCIG). To identify predisposing factors for anti-IgA antibodies and related anaphytactoid reactions, we analyzed the clinical and immunological phenotype of affected patients. All eight IgG anti-IgA-positive patients tacked IgA(+) B cells in peripheral blood. Moreover, CVID patients with retained class-switched CD27(pos) IgM(neg) IgD(neg) memory B cells (Freiburg classification group II) and total IgA deficiency seem to have an increased risk for developing anti-IgA antibodies. In seven of the eight patients, lymphoproliferation was observed (most prominently nodular lymphatic hyperplasia), two had granulomatous disease, and two showed autoimmune phenomena.
ER  -

HORN, J., Vojtěch THON, D. BARTONKOVA, U. SALZER, K. WARNATZ, M. SCHLESIER, HH. PETER and B. GRIMBACHER. Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy. \textit{CLINICAL IMMUNOLOGY}. 2007, vol.~122, No~2, p.~156-162. ISSN~1521-6616.

Detailed Information on Publication Record