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@article{837062,
author = {Spatz, M. and Wolf, HM. and Thon, Vojtěch and Gampfer, JM. and Eibl, MM.},
article_number = {1},
keywords = {T CELL CLONES; PRIMARY GENITAL HERPES; NECROSIS FACTOR ALPHA; VIRUS TYPE 1; DENDRITIC CELLS; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; GENE EXPRESSION;},
language = {eng},
issn = {0146-6615},
journal = {JOURNAL OF MEDICAL VIROLOGY},
title = {Immune response to the herpes simplex type 1 regulatory proteins ICP8 and VP16 in infected persons},
volume = {62},
year = {2000}
}
TY - JOUR
ID - 837062
AU - Spatz, M. - Wolf, HM. - Thon, Vojtěch - Gampfer, JM. - Eibl, MM.
PY - 2000
TI - Immune response to the herpes simplex type 1 regulatory proteins ICP8 and VP16 in infected persons
JF - JOURNAL OF MEDICAL VIROLOGY
VL - 62
IS - 1
SP - 29-36
EP - 29-36
SN - 01466615
KW - T CELL CLONES
KW - PRIMARY GENITAL HERPES
KW - NECROSIS FACTOR ALPHA
KW - VIRUS TYPE 1
KW - DENDRITIC CELLS
KW - ANTIBODY RESPONSE
KW - ANTIGEN PRESENTATION
KW - GENE EXPRESSION;
N2 - The specific immune responses directed against the viral single stranded (ss) DNA binding protein ICP8 and the transactivator of immediate early (IE) gene expression VP16 (alpha-trans inducing factor, Vmw65) in HSV type 1 seropositive humans were examined. The results described in this paper indicate that neither ICP8 nor VP16 were able to induce a recall response in lymphocytes of healthy HSV seropositive individuals without recurrent infection, although CD4+ T cells purified from these individuals responded to both viral proteins in vitro when monocyte derived dendritic cells were used as antigen presenting cells. A recall response, however, could be induced to both viral proteins in T cells of patients with recurrent HSV infections when blood monocytes were used. Moreover, ICP8- and VP16-specific antibodies could be detected in the serum of patients with recurrent HSV infections whereas, in contrast, these antibodies were virtually absent in healthy HSV seropositive individuals without recurrences. These data represent the first systematic study of the immunological properties of ICP8 in humans, indicating a significant difference in the response to the essential viral regulators ICP8 and VP16 in HSV-1 seropositive healthy individuals as opposed to patients with recurrent HSV-1 infections.
ER -
SPATZ, M., HM. WOLF, Vojtěch THON, JM. GAMPFER and MM. EIBL. Immune response to the herpes simplex type 1 regulatory proteins ICP8 and VP16 in infected persons. \textit{JOURNAL OF MEDICAL VIROLOGY}. 2000, vol.~62, No~1, p.~29-36. ISSN~0146-6615.
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