Podrobný výpis o publikaci

FISCHER, MB., I. HAUBER, M. FODINGER, HM. WOLF, Vojtěch THON, P. DONATH, MM. EIBL a RM, KNOBLER. DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA. JOURNAL OF INVESTIGATIVE DERMATOLOGY. roč. 104, č. 4, s. 537-540. ISSN 0022-202X. 1995.

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Základní údaje
Originální název	DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA
Název česky	Porušená exprese TCR asociovaná s poruchou beta řetězce receptoru TCR u pacienta s kožním T buněčným lymfomem
Autoři	FISCHER, MB. (40 Rakousko), I. HAUBER (276 Německo), M. FODINGER (40 Rakousko), HM. WOLF (40 Rakousko), Vojtěch THON (203 Česká republika, garant), P. DONATH (40 Rakousko), MM. EIBL (40 Rakousko) a RM, KNOBLER (642 Rumunsko).
Vydání	JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 0022-202X.

Další údaje
Originální jazyk	angličtina
Typ výsledku	Článek v odborném periodiku
Obor	30102 Immunology
Stát vydavatele	Velká Británie a Severní Irsko
Utajení	není předmětem státního či obchodního tajemství
Kód RIV	RIV/00216224:14110/95:00035802
Organizační jednotka	Lékařská fakulta
UT WoS	A1995QR53200021
Klíčová slova česky	TCR; T lymfom
Klíčová slova anglicky	RECEPTOR COMPLEX; LYMPHOCYTES T; ANTIGEN; SEQUENCE; SUBUNITS; T cell lymphoma
Štítky	ANTIGEN, LYMPHOCYTES T, RECEPTOR COMPLEX, SEQUENCE, SUBUNITS, T cell lymphoma
Příznaky	Mezinárodní význam, Recenzováno
Změnil	Změnil: prof. MUDr. Vojtěch Thon, Ph.D., učo 2483. Změněno: 26. 6. 2009 00:25.

Anotace
We report on a patient with cutaneous T-cell lymphoma (CTCL) of long-standing duration. Phenotypic analysis of his peripheral blood mononuclear cells revealed an increased CD4(+) T-helper subset and a decreased CD8(+) cytotoxic T-cell population. Eighty-three to ninety-three percent of the patient's CD4(+) T cells in the peripheral blood and 70% of the CD4(+) T cells in the lesional skin lacked surface expression of the TCR/CD3 complex and showed a clonal rearrangement pattern of the TCR gamma-chain gene (V11-J1/J2). The lack in TCR surface expression correlated with defective assembly of the TCR beta-chain. Although mRNA for the TCR constant region beta 1 was found in the patient's purified CD4(+)TCR(-)CD3(-) T cells, no intracytoplasmic TCR beta protein was detectable. In contrast, the patient's purified CD4(+)TCR(-)CD3(-) T cells not only expressed mRNA specific for the TCR alpha-chain and for all CD3 chains, but intracytoplasmic TCR alpha and CD3 epsilon proteins could also be found. The lack of TCR beta protein clearly explains the defective surface expression of the TCR/CD3 complex in the patient's malignant T cells.

Anotace

We report on a patient with cutaneous T-cell lymphoma (CTCL) of long-standing duration. Phenotypic analysis of his peripheral blood mononuclear cells revealed an increased CD4(+) T-helper subset and a decreased CD8(+) cytotoxic T-cell population. Eighty-three to ninety-three percent of the patient's CD4(+) T cells in the peripheral blood and 70% of the CD4(+) T cells in the lesional skin lacked surface expression of the TCR/CD3 complex and showed a clonal rearrangement pattern of the TCR gamma-chain gene (V11-J1/J2). The lack in TCR surface expression correlated with defective assembly of the TCR beta-chain. Although mRNA for the TCR constant region beta 1 was found in the patient's purified CD4(+)TCR(-)CD3(-) T cells, no intracytoplasmic TCR beta protein was detectable. In contrast, the patient's purified CD4(+)TCR(-)CD3(-) T cells not only expressed mRNA specific for the TCR alpha-chain and for all CD3 chains, but intracytoplasmic TCR alpha and CD3 epsilon proteins could also be found. The lack of TCR beta protein clearly explains the defective surface expression of the TCR/CD3 complex in the patient's malignant T cells.

Anotace česky
Porušená exprese TCR asociovaná s poruchou beta řetězce receptoru TCR u pacienta s kožním T buněčným lymfomem.