FISCHER, MB., I. HAUBER, M. FODINGER, HM. WOLF, Vojtěch THON, P. DONATH, MM. EIBL and RM, KNOBLER. DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1995, vol. 104, No 4, p. 537-540. ISSN 0022-202X.
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Basic information
Original name DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA
Name in Czech Porušená exprese TCR asociovaná s poruchou beta řetězce receptoru TCR u pacienta s kožním T buněčným lymfomem
Authors FISCHER, MB. (40 Austria), I. HAUBER (276 Germany), M. FODINGER (40 Austria), HM. WOLF (40 Austria), Vojtěch THON (203 Czech Republic, guarantor), P. DONATH (40 Austria), MM. EIBL (40 Austria) and RM, KNOBLER (642 Romania).
Edition JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 0022-202X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30102 Immunology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/95:00035802
Organization unit Faculty of Medicine
UT WoS A1995QR53200021
Keywords (in Czech) TCR; T lymfom
Keywords in English RECEPTOR COMPLEX; LYMPHOCYTES T; ANTIGEN; SEQUENCE; SUBUNITS; T cell lymphoma
Tags ANTIGEN, LYMPHOCYTES T, RECEPTOR COMPLEX, SEQUENCE, SUBUNITS, T cell lymphoma
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Vojtěch Thon, Ph.D., učo 2483. Changed: 26/6/2009 00:25.
Abstract
We report on a patient with cutaneous T-cell lymphoma (CTCL) of long-standing duration. Phenotypic analysis of his peripheral blood mononuclear cells revealed an increased CD4(+) T-helper subset and a decreased CD8(+) cytotoxic T-cell population. Eighty-three to ninety-three percent of the patient's CD4(+) T cells in the peripheral blood and 70% of the CD4(+) T cells in the lesional skin lacked surface expression of the TCR/CD3 complex and showed a clonal rearrangement pattern of the TCR gamma-chain gene (V11-J1/J2). The lack in TCR surface expression correlated with defective assembly of the TCR beta-chain. Although mRNA for the TCR constant region beta 1 was found in the patient's purified CD4(+)TCR(-)CD3(-) T cells, no intracytoplasmic TCR beta protein was detectable. In contrast, the patient's purified CD4(+)TCR(-)CD3(-) T cells not only expressed mRNA specific for the TCR alpha-chain and for all CD3 chains, but intracytoplasmic TCR alpha and CD3 epsilon proteins could also be found. The lack of TCR beta protein clearly explains the defective surface expression of the TCR/CD3 complex in the patient's malignant T cells.
Abstract (in Czech)
Porušená exprese TCR asociovaná s poruchou beta řetězce receptoru TCR u pacienta s kožním T buněčným lymfomem.
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