HLA DRB1,DQB1 and insulin promoter VNTR polymorphisms:interactions and the association with adult-onset diabetes mellitus in Czech patiens

ČEJKOVÁ, P., Peter NOVOTA, M. ČERNÁ, Zuzana KOLOŠTOVÁ, D. NOVAKOVA, P. KUČERA, M. ANDEL, Pavel WEBER and E. ŽĎÁRSKÝ. HLA DRB1,DQB1 and insulin promoter VNTR polymorphisms:interactions and the association with adult-onset diabetes mellitus in Czech patiens. International Journal of immunogenetics. 2008, vol. 35, No 1, p. 133-144. ISSN 1744-3121.

Basic information

Original name

HLA DRB1,DQB1 and insulin promoter VNTR polymorphisms:interactions and the association with adult-onset diabetes mellitus in Czech patiens

Name in Czech

HLA DRB1,DQB1 a INSVNT polyformismy interakce a asociace u diabetiků začínající v dospělém věku

Authors

ČEJKOVÁ, P. (203 Czech Republic), Peter NOVOTA (703 Slovakia, guarantor), M. ČERNÁ (203 Czech Republic), Zuzana KOLOŠTOVÁ (703 Slovakia), D. NOVAKOVA (203 Czech Republic), P. KUČERA (203 Czech Republic), M. ANDEL (203 Czech Republic), Pavel WEBER (203 Czech Republic) and E. ŽĎÁRSKÝ (203 Czech Republic)

Edition

International Journal of immunogenetics, 2008, 1744-3121

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.160

RIV identification code

RIV/00216224:14110/08:00035816

Organization unit

Faculty of Medicine

UT WoS

000253758400008

Keywords (in Czech)

HLA DRB1 DQB1

Keywords in English

HLA DRB1 DQB1

Tags

HLA DRB1 DQB1

Tags

International impact

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Abstract

V originále

Both the human leucocyte antigen (HLA) BRB1 and the HLA BRB1 gene loci play a role in the development and progression of autoimmune diabetes mellitus (T1DM).Similarly, the insulin promoter variable number tandem repeats (INS-VNTR) polymorphism is also involved in the pathogenesis of diabetes mellitus (DM). We studied the association between each of these polymorphisms and DM diagnosed in patients older than age 35 years. Furthermore, we analysed possible interactions between HLA BRB1/DQB1 and INS-VNTR polymorphisms.

In Czech

Oba lidské leukocytární antigeny HLA DRB1 a HLA DQB1 hrají roli ve vývoji a progresi onemocnění autoimunitním DM /typ 1/. Taktéž polymorfismus Insulin promoter variable number tandem repeats /INS-VNTR/ hraje roli při patogenezi DM. Studovali jsme asociaci mezi každým takovým polymorfismem a DM diagnostikovaným u pacientů starších 35 let. Dále jsme analyzovali možné interakce mezi HLA DRB1/DQB1 a INS-VNTR polymorfismy.