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@article{837731, author = {Nováková, Jana and Slabý, Ondřej and Vyzula, Rostislav and Michálek, Jaroslav}, article_location = {San Diego (USA)}, article_number = {1}, keywords = {MicroRNA; Glioblastoma;Pathogenesis;Apoptosis;Cell cycle}, language = {eng}, issn = {0006-291X}, journal = {Biochemical and Biophysical Research Communications}, title = {MicroRNA involvement in glioblastoma pathogenesis}, url = {http://www.sciencedirect.com/science/journal/0006291X}, volume = {386}, year = {2009} }
TY - JOUR ID - 837731 AU - Nováková, Jana - Slabý, Ondřej - Vyzula, Rostislav - Michálek, Jaroslav PY - 2009 TI - MicroRNA involvement in glioblastoma pathogenesis JF - Biochemical and Biophysical Research Communications VL - 386 IS - 1 SP - 1-5 EP - 1-5 PB - Elsevier SN - 0006291X KW - MicroRNA KW - Glioblastoma;Pathogenesis;Apoptosis;Cell cycle UR - http://www.sciencedirect.com/science/journal/0006291X N2 - MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression levels of several microRNAs have been observed in glioblastomas. Functions and direct mRNA targets for these microRNAs have been relatively well studied over the last years. According to these data, it is now evident, that impairment of microRNA regulatory network is one of the key mechanisms in glioblastoma pathogenesis. microRNA deregulation is involved in processes such as cell proliferation, apoptosis, cell cycle regulation, invasion, glioma stem cell behavior and angiogenesis. In this review, we summarize the current knowledge of miRNA functions in glioblastoma with an emphasis on its significance in glioblastoma oncogenic signaling and its potential to serve as a disease biomarker and a novel therapeutic target in oncology. ER -
NOVÁKOVÁ, Jana, Ondřej SLABÝ, Rostislav VYZULA and Jaroslav MICHÁLEK. MicroRNA involvement in glioblastoma pathogenesis. \textit{Biochemical and Biophysical Research Communications}. San Diego (USA): Elsevier, 2009, vol.~386, No~1, p.~1-5. ISSN~0006-291X.
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