J 2009

MicroRNA involvement in glioblastoma pathogenesis

NOVÁKOVÁ, Jana, Ondřej SLABÝ, Rostislav VYZULA and Jaroslav MICHÁLEK

Basic information

Original name

MicroRNA involvement in glioblastoma pathogenesis

Name in Czech

Zapojení mikroRNA do patogeneze glioblastomu

Authors

NOVÁKOVÁ, Jana (203 Czech Republic), Ondřej SLABÝ (203 Czech Republic, guarantor), Rostislav VYZULA (203 Czech Republic) and Jaroslav MICHÁLEK (203 Czech Republic)

Edition

Biochemical and Biophysical Research Communications, San Diego (USA), Elsevier, 2009, 0006-291X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Greece

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 2.548

RIV identification code

RIV/00216224:14110/09:00035862

Organization unit

Faculty of Medicine

UT WoS

000267868800001

Keywords (in Czech)

mikroRNA; glioblastom; patogeneze; apoptoza; buněčný cyklus

Keywords in English

MicroRNA; Glioblastoma;Pathogenesis;Apoptosis;Cell cycle

Tags

Tags

International impact, Reviewed
Změněno: 30/9/2010 15:41, prof. RNDr. Ondřej Slabý, Ph.D.

Abstract

ORIG CZ

V originále

MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression levels of several microRNAs have been observed in glioblastomas. Functions and direct mRNA targets for these microRNAs have been relatively well studied over the last years. According to these data, it is now evident, that impairment of microRNA regulatory network is one of the key mechanisms in glioblastoma pathogenesis. microRNA deregulation is involved in processes such as cell proliferation, apoptosis, cell cycle regulation, invasion, glioma stem cell behavior and angiogenesis. In this review, we summarize the current knowledge of miRNA functions in glioblastoma with an emphasis on its significance in glioblastoma oncogenic signaling and its potential to serve as a disease biomarker and a novel therapeutic target in oncology.

In Czech

MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression levels of several microRNAs have been observed in glioblastomas. Functions and direct mRNA targets for these microRNAs have been relatively well studied over the last years. According to these data, it is now evident, that impairment of microRNA regulatory network is one of the key mechanisms in glioblastoma pathogenesis. microRNA deregulation is involved in processes such as cell proliferation, apoptosis, cell cycle regulation, invasion, glioma stem cell behavior and angiogenesis. In this review, we summarize the current knowledge of miRNA functions in glioblastoma with an emphasis on its significance in glioblastoma oncogenic signaling and its potential to serve as a disease biomarker and a novel therapeutic target in oncology.

Links

NS9875, research and development project
Name: Studium mechanismu imunorezistence glioblastomu