| PARUCH, Kamil, Michael DWYER, Carmen ALVAREZ, Courtney BROWN, Tin-Yau CHAN, Ronald DOLL, Kerry KEERTIKAR, Chad KNUTSON, Brian MCKITTRICK, Jocelyn RIVERA, Randall ROSSMAN, Greg TUCKER, Thierry FISCHMANN, Alan HRUZA, Vincent MADISON, Amin NOMEIR, Yaolin WANG, Emma LEES, David PARRY, Nicole SGAMBELLONE, Wolfgang SEGHEZZI, Lesley SCHULTZ, Fran SHANAHAN, Derek WISWELL, Xiaoying XU, Quiao ZHOU, Ray JAMES, Vidyadhar PARADKAR, Haengsoon PARK, Laura ROKOSZ, Tara STAUFFER and Timothy GUZI. Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2. Bioorganic & Medicinal Chemistry Letters. 2007, vol. 2007, No 17, p. 6220-6223. ISSN 0960-894X. |
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@article{837811,
author = {Paruch, Kamil and Dwyer, Michael and Alvarez, Carmen and Brown, Courtney and Chan, TinandYau and Doll, Ronald and Keertikar, Kerry and Knutson, Chad and McKittrick, Brian and Rivera, Jocelyn and Rossman, Randall and Tucker, Greg and Fischmann, Thierry and Hruza, Alan and Madison, Vincent and Nomeir, Amin and Wang, Yaolin and Lees, Emma and Parry, David and Sgambellone, Nicole and Seghezzi, Wolfgang and Schultz, Lesley and Shanahan, Fran and Wiswell, Derek and Xu, Xiaoying and Zhou, Quiao and James, Ray and Paradkar, Vidyadhar and Park, Haengsoon and Rokosz, Laura and Stauffer, Tara and Guzi, Timothy},
article_number = {17},
keywords = {CDK2 kinase; inibitor; cancer},
language = {eng},
issn = {0960-894X},
journal = {Bioorganic & Medicinal Chemistry Letters},
title = {Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2},
url = {http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4PMJJYW-5&_user=835458&_coverDate=11%2F15%2F2007&_alid=963411855&_rdoc=2&_fmt=high&_orig=search&_cdi=5221&_sort=r&_docanchor=&view=c&_ct=2&_acct=C000045159&_version=1&_urlVersion=0&_us},
volume = {2007},
year = {2007}
}
TY - JOUR
ID - 837811
AU - Paruch, Kamil - Dwyer, Michael - Alvarez, Carmen - Brown, Courtney - Chan, Tin-Yau - Doll, Ronald - Keertikar, Kerry - Knutson, Chad - McKittrick, Brian - Rivera, Jocelyn - Rossman, Randall - Tucker, Greg - Fischmann, Thierry - Hruza, Alan - Madison, Vincent - Nomeir, Amin - Wang, Yaolin - Lees, Emma - Parry, David - Sgambellone, Nicole - Seghezzi, Wolfgang - Schultz, Lesley - Shanahan, Fran - Wiswell, Derek - Xu, Xiaoying - Zhou, Quiao - James, Ray - Paradkar, Vidyadhar - Park, Haengsoon - Rokosz, Laura - Stauffer, Tara - Guzi, Timothy
PY - 2007
TI - Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2
JF - Bioorganic & Medicinal Chemistry Letters
VL - 2007
IS - 17
SP - 6220-6223
EP - 6220-6223
SN - 0960894X
KW - CDK2 kinase
KW - inibitor
KW - cancer
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4PMJJYW-5&_user=835458&_coverDate=11%2F15%2F2007&_alid=963411855&_rdoc=2&_fmt=high&_orig=search&_cdi=5221&_sort=r&_docanchor=&view=c&_ct=2&_acct=C000045159&_version=1&_urlVersion=0&_us
N2 - Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model.
ER -
PARUCH, Kamil, Michael DWYER, Carmen ALVAREZ, Courtney BROWN, Tin-Yau CHAN, Ronald DOLL, Kerry KEERTIKAR, Chad KNUTSON, Brian MCKITTRICK, Jocelyn RIVERA, Randall ROSSMAN, Greg TUCKER, Thierry FISCHMANN, Alan HRUZA, Vincent MADISON, Amin NOMEIR, Yaolin WANG, Emma LEES, David PARRY, Nicole SGAMBELLONE, Wolfgang SEGHEZZI, Lesley SCHULTZ, Fran SHANAHAN, Derek WISWELL, Xiaoying XU, Quiao ZHOU, Ray JAMES, Vidyadhar PARADKAR, Haengsoon PARK, Laura ROKOSZ, Tara STAUFFER and Timothy GUZI. Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2. \textit{Bioorganic \&{} Medicinal Chemistry Letters}. 2007, vol.~2007, No~17, p.~6220-6223. ISSN~0960-894X.
|
