International Staging System required standardization of
biochemical laboratory testing in multiple myeloma

J 2006

International Staging System required standardization of biochemical laboratory testing in multiple myeloma

TICHÝ, M., Vladimír MAISNAR, Vladimír PALIČKA, Bedřich FRIEDECKÝ, J. VÁVROVÁ et. al.

Basic information

Original name

International Staging System required standardization of biochemical laboratory testing in multiple myeloma

Name in Czech

Standardizace biochemických laboratorních markerů pro diagnostiku mnohočetného myelomu

Authors

TICHÝ, M. (203 Czech Republic), Vladimír MAISNAR (203 Czech Republic), Vladimír PALIČKA (203 Czech Republic), Bedřich FRIEDECKÝ (203 Czech Republic), J. VÁVROVÁ (203 Czech Republic), H. NOVOTNÁ (203 Czech Republic), Z. ČERMÁKOVÁ (203 Czech Republic), M. DASTYCH (203 Czech Republic), P. ČECHÁK (203 Czech Republic), D. VOGTOVÁ (203 Czech Republic), E. JAROLÍMKOVÁ (203 Czech Republic), H. BENÁKOVÁ (203 Czech Republic), L. HACHOVÁ (203 Czech Republic), D. BEZDÍČKOVÁ (203 Czech Republic), F. KOUŘIL (203 Czech Republic), EA. ZÁBRANSKÁ (203 Czech Republic), J. ZENKOVÁ (203 Czech Republic), P. SLABÝ (203 Czech Republic), V. ŠČUDLA (203 Czech Republic), E. GREGORA (203 Czech Republic), Ivan ŠPIČKA (203 Czech Republic), J. ŠTRAUB (203 Czech Republic), M. SCHÜTZOVÁ (203 Czech Republic) and Roman HÁJEK (203 Czech Republic, guarantor)

Edition

Neoplasma, Slovakia, Slovak Academic Press Ltd. 2006, 0028-2685

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.247

RIV identification code

RIV/00216224:14110/06:00035892

Organization unit

Faculty of Medicine

UT WoS

000243359900006

Keywords (in Czech)

mnohočetný myelom;

Keywords in English

multiple myeloma;

Abstract

ORIG CZ

V originále

The standardization of biochemical measurement procedures in multiple myeloma is necessary for reliable prognostic stratification of patients in multicentric trials. The new prognostic index International Staging System for multiple myeloma uses only two laboratory markers, albumin and beta-2 microglobulin. Our study compared results of albumin, beta-2 microglobulin and monoclonal immunoglobulin measurements from six centers which provide treatment for multiple myeloma in the Czech Republic and attempted to standardize the analytic procedures. We have found that the measurement of albumin is well standardized and the results from all laboratories were comparable. The measurement of beta-2 microglobulin achieved comparability only after a partial unification of analytical methods. The determination of monoclonal immunoglobulin concentration provided comparable results for concentrations higher than 20 g/l with higher variability for lower values.

In Czech

V této práci jsou porovnány výsledky stanovování laboratorních markerů (albuminu, monoklonálního imunoglobulinu a beta-2 mikroglobulinu) z 6 center v České republice.

Citovat

TICHÝ, M., Vladimír MAISNAR, Vladimír PALIČKA, Bedřich FRIEDECKÝ, J. VÁVROVÁ, H. NOVOTNÁ, Z. ČERMÁKOVÁ, M. DASTYCH, P. ČECHÁK, D. VOGTOVÁ, E. JAROLÍMKOVÁ, H. BENÁKOVÁ, L. HACHOVÁ, D. BEZDÍČKOVÁ, F. KOUŘIL, EA. ZÁBRANSKÁ, J. ZENKOVÁ, P. SLABÝ, V. ŠČUDLA, E. GREGORA, Ivan ŠPIČKA, J. ŠTRAUB, M. SCHÜTZOVÁ and Roman HÁJEK. International Staging System required standardization of biochemical laboratory testing in multiple myeloma. Neoplasma. Slovakia: Slovak Academic Press Ltd., 2006, vol. 53, No 6, p. 492-494. ISSN 0028-2685.

@article{837895,
   author = {Tichý, M. and Maisnar, Vladimír and Palička, Vladimír and Friedecký, Bedřich and Vávrová, J. and Novotná, H. and Čermáková, Z. and Dastych, M. and Čechák, P. and Vogtová, D. and Jarolímková, E. and Benáková, H. and Hachová, L. and Bezdíčková, D. and Kouřil, F. and Zábranská, EA. and Zenková, J. and Slabý, P. and Ščudla, V. and Gregora, E. and Špička, Ivan and Štraub, J. and Schützová, M. and Hájek, Roman},
   article_location = {Slovakia},
   article_number = {6},
   keywords = {multiple myeloma;},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {International Staging System required standardization of biochemical laboratory testing in multiple myeloma},
   volume = {53},
   year = {2006}
}

TY  - JOUR
ID  - 837895
AU  - Tichý, M. - Maisnar, Vladimír - Palička, Vladimír - Friedecký, Bedřich - Vávrová, J. - Novotná, H. - Čermáková, Z. - Dastych, M. - Čechák, P. - Vogtová, D. - Jarolímková, E. - Benáková, H. - Hachová, L. - Bezdíčková, D. - Kouřil, F. - Zábranská, EA. - Zenková, J. - Slabý, P. - Ščudla, V. - Gregora, E. - Špička, Ivan - Štraub, J. - Schützová, M. - Hájek, Roman
PY  - 2006
TI  - International Staging System required standardization of biochemical laboratory testing in multiple myeloma
JF  - Neoplasma
VL  - 53
IS  - 6
SP  - 492-494
EP  - 492-494
PB  - Slovak Academic Press Ltd.
SN  - 00282685
KW  - multiple myeloma;
N2  - The standardization of biochemical measurement procedures in multiple myeloma is necessary for reliable prognostic stratification of patients in multicentric trials. The new prognostic index International Staging System for multiple myeloma uses only two laboratory markers, albumin and beta-2 microglobulin. Our study compared results of albumin, beta-2 microglobulin and monoclonal immunoglobulin measurements from six centers which provide treatment for multiple myeloma in the Czech Republic and attempted to standardize the analytic procedures. We have found that the measurement of albumin is well standardized and the results from all laboratories were comparable. The measurement of beta-2 microglobulin achieved comparability only after a partial unification of analytical methods. The determination of monoclonal immunoglobulin concentration provided comparable results for concentrations higher than 20 g/l with higher variability for lower values.
ER  -

TICHÝ, M., Vladimír MAISNAR, Vladimír PALIČKA, Bedřich FRIEDECKÝ, J. VÁVROVÁ, H. NOVOTNÁ, Z. ČERMÁKOVÁ, M. DASTYCH, P. ČECHÁK, D. VOGTOVÁ, E. JAROLÍMKOVÁ, H. BENÁKOVÁ, L. HACHOVÁ, D. BEZDÍČKOVÁ, F. KOUŘIL, EA. ZÁBRANSKÁ, J. ZENKOVÁ, P. SLABÝ, V. ŠČUDLA, E. GREGORA, Ivan ŠPIČKA, J. ŠTRAUB, M. SCHÜTZOVÁ and Roman HÁJEK. International Staging System required standardization of biochemical laboratory testing in multiple myeloma. \textit{Neoplasma}. Slovakia: Slovak Academic Press Ltd., 2006, vol.~53, No~6, p.~492-494. ISSN~0028-2685.

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