2-Fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors

PARUCH, Kamil, Timothy GUZI and Michael DWYER. 2-Fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors. 2009.

Basic information

Original name

2-Fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors

Name in Czech

2-Fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors

Authors

PARUCH, Kamil, Timothy GUZI and Michael DWYER

Edition

Number: WO 2009/070567 A1, Publisher: World Intellectual Property Organization, Place of publication: USA, Owner's name: Schering-Plough, 2009

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Other information

Language

English

Type of outcome

Patent

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Science

Keywords (in Czech)

protein kinase; inhibitor; pyrazolopyrimidine

Keywords in English

protein kinase; inhibitor; pyrazolopyrimidine

Tags

inhibitor, protein kinase, pyrazolopyrimidine

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Abstract

V originále

Title compds. represented by the formula I [wherein R3 = H, (cyclo)alkyl, alkynyl, etc.; R5, R7 = independently H, (amino)alkyl, aryl, etc.; R6 = H, halo, (hetero)aryl, etc.; and pharmaceutically acceptable salts, solvates,esters prodrugs or stereoisomers thereof] were prepd. as protein kinase inhibitors (no data). For example, II was provided in a multi-step synthesis starting from the reaction of 1-Boc-piperidine-3-carboxylic acid with Meldrum's acid. Pyrazolo[1,5-a]pyrimidine-based inhibitors of various kinase, compns. including the inhibitors, and methods of using the inhibitors and inhibitor compns. are described. The invention also provides for methods of making CDK-2 or CHK-1 inhibitor compds., methods of inhibiting CDK-2 or CHK-1, and methods for treating disease or disease symptoms.

In Czech

viz anotace