Detailed Information on Publication Record
2005
Prognostic factors for survival after autologous transplantation: a single centre experience in 133 multiple myeloma patients.
KREJČÍ, Marta, Tomáš BÜCHLER, Roman HÁJEK, A. SVOBODNÍK, Andrea KŘIVANOVÁ et. al.Basic information
Original name
Prognostic factors for survival after autologous transplantation: a single centre experience in 133 multiple myeloma patients.
Name in Czech
Prognostické faktory přežití po autologní transplantaci: zkušenosti jednoho centra se 133 pacienty s mnohočetným myelomem
Authors
KREJČÍ, Marta (203 Czech Republic, guarantor), Tomáš BÜCHLER (703 Slovakia), Roman HÁJEK (203 Czech Republic), A. SVOBODNÍK (203 Czech Republic), Andrea KŘIVANOVÁ (203 Czech Republic), Luděk POUR (203 Czech Republic), Zdeněk ADAM (203 Czech Republic), Jiří MAYER (203 Czech Republic) and Jiří VORLÍČEK (203 Czech Republic)
Edition
Bone Marrow Transplantation, London, Nature Publishing Group, 2005, 0268-3369
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.643
RIV identification code
RIV/00216224:14110/05:00035910
Organization unit
Faculty of Medicine
UT WoS
000226245100008
Keywords (in Czech)
mnohočetný myelom
Keywords in English
multiple myeloma; autologous stem cell transplantation
Tags
Změněno: 10/2/2010 07:08, Mgr. Anna Potáčová, Ph.D.
V originále
Autologous stem cell transplantation (ASCT) has an established role in the treatment of symptomatic multiple myeloma (MM). Our aim was to analyse the impact of selected prognostic parameters on the survival of patients with MM after ASCT. The new International Staging System (ISS) was also evaluated. A total of 133 MM patients were transplanted in our centre between 1995 and 2002. Following ASCT, 35% of patients were in complete remission (CR) and 60% were in partial remission (PR). The median progression-free (PFS) and overall (OS) survival from transplantation were 29.5 and 68.8 months, respectively. Transplant-related mortality (TRM) was 3%. On multivariate analysis, factors associated with significantly shorter OS were lack of CR after transplant (P = 0.002, hazard ratio (HR): 3.1), stage 3 according to ISS (P = 0.001, HR: 3.0) and age at transplant over 60 years (P = 0.035, HR: 2.0). The status of disease before ASCT did not significantly affect PFS and OS after transplantation. We conclude that ASCT is a safe and effective procedure in MM patients, associated with low TRM. The survival after ASCT was dependent on response after ASCT, stage according to ISS and age.
In Czech
Cílem této práce bylo srovnat význam vybraných prognostických parametrů na přežívání pacientů s MM po transplantaci.