| BÜCHLER, Tomáš, Jaroslav MICHÁLEK, Lucie KOVÁŘOVÁ, R. MUSILOVÁ and Roman HÁJEK. Dendritic cell-based immunotherapy for the treatment of hematological malignancies. Hematology. England: Maney Pub., 2003, vol. 8, No 2, p. 97-104. ISSN 1024-5332. |
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@article{838020,
author = {Büchler, Tomáš and Michálek, Jaroslav and Kovářová, Lucie and Musilová, R. and Hájek, Roman},
article_location = {England},
article_number = {2},
keywords = {dendritic cell; hematological malignancies; immunotherapy},
language = {eng},
issn = {1024-5332},
journal = {Hematology},
title = {Dendritic cell-based immunotherapy for the treatment of hematological malignancies},
volume = {8},
year = {2003}
}
TY - JOUR
ID - 838020
AU - Büchler, Tomáš - Michálek, Jaroslav - Kovářová, Lucie - Musilová, R. - Hájek, Roman
PY - 2003
TI - Dendritic cell-based immunotherapy for the treatment of hematological malignancies
JF - Hematology
VL - 8
IS - 2
SP - 97-104
EP - 97-104
PB - Maney Pub.
SN - 10245332
KW - dendritic cell
KW - hematological malignancies
KW - immunotherapy
N2 - Dendritic cells (DCs) are professional antigen-presenting cells and are frequently used in current immunotherapy protocols. The administration of DCs loaded with tumor-associated proteins or peptides results in the induction of immune responses against different types of malignant cells. Methods for large-scale generation of DCs in a sufficient quality and quantity have permitted their use in clinical experiments. DC-based vaccines have already shown promise in follicular non-Hodgkin's lymphoma, and to some extent, in other hematological malignancies. Several strategies have been developed to boost their potency as a new and relatively non-toxic treatment modality. Our review focuses on clinical trials using DCs in the treatment of hematologic malignancies and on recent studies of the immunophenotype, development, and maturation of DCs may have an important impact on designing DC-based antitumor vaccines.
ER -
BÜCHLER, Tomáš, Jaroslav MICHÁLEK, Lucie KOVÁŘOVÁ, R. MUSILOVÁ and Roman HÁJEK. Dendritic cell-based immunotherapy for the treatment of hematological malignancies. \textit{Hematology}. England: Maney Pub., 2003, vol.~8, No~2, p.~97-104. ISSN~1024-5332.
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