Dendritic cell-based immunotherapy for the treatment of hematological malignancies

BÜCHLER, Tomáš, Jaroslav MICHÁLEK, Lucie KOVÁŘOVÁ, R. MUSILOVÁ and Roman HÁJEK. Dendritic cell-based immunotherapy for the treatment of hematological malignancies. Hematology. England: Maney Pub., 2003, vol. 8, No 2, p. 97-104. ISSN 1024-5332.

Basic information

Original name

Dendritic cell-based immunotherapy for the treatment of hematological malignancies

Name in Czech

Imunoterapie založená na dendritických buňkách při léčbě hematologických malignit

Authors

BÜCHLER, Tomáš (703 Slovakia), Jaroslav MICHÁLEK (203 Czech Republic), Lucie KOVÁŘOVÁ (203 Czech Republic), R. MUSILOVÁ (203 Czech Republic) and Roman HÁJEK (203 Czech Republic, guarantor)

Edition

Hematology, England, Maney Pub. 2003, 1024-5332

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

Keywords (in Czech)

dendritické buňky; hematoonkologie; imunoterapie

Keywords in English

dendritic cell; hematological malignancies; immunotherapy

Tags

dendritic cell, hematological malignancies, Immunotherapy

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Abstract

V originále

Dendritic cells (DCs) are professional antigen-presenting cells and are frequently used in current immunotherapy protocols. The administration of DCs loaded with tumor-associated proteins or peptides results in the induction of immune responses against different types of malignant cells. Methods for large-scale generation of DCs in a sufficient quality and quantity have permitted their use in clinical experiments. DC-based vaccines have already shown promise in follicular non-Hodgkin's lymphoma, and to some extent, in other hematological malignancies. Several strategies have been developed to boost their potency as a new and relatively non-toxic treatment modality. Our review focuses on clinical trials using DCs in the treatment of hematologic malignancies and on recent studies of the immunophenotype, development, and maturation of DCs may have an important impact on designing DC-based antitumor vaccines.

In Czech

Toto review je zaměřeno na klinické studie využivajících k léčbě hematoonkologických onemocnění dendritických buněk.