Imidazopyrazines as protein kinase inhibitors

ZHAO, Lianyun, Panduranga Adulla REDDY, Neng-Yang SHIH, Kamil PARUCH, Timothy GUZI and Arshad SIDDIQUI. Imidazopyrazines as protein kinase inhibitors. 2007.

Basic information

Original name

Imidazopyrazines as protein kinase inhibitors

Name in Czech

Imidazopyrazines as protein kinase inhibitors

Authors

ZHAO, Lianyun, Panduranga Adulla REDDY, Neng-Yang SHIH, Kamil PARUCH, Timothy GUZI and Arshad SIDDIQUI

Edition

Number: WO 2007/145921 A1, Publisher: World Intellectual Property Organization, Place of publication: USA, Owner's name: Schering-Plough, 2007

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Other information

Language

English

Type of outcome

Patent

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Science

Keywords (in Czech)

imidazopyrazines; kinase; inhibitor

Keywords in English

imidazopyrazines; kinase; inhibitor

Tags

imidazopyrazines, inhibitor, Kinase

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Abstract

V originále

The invention provides a class of imidazopyrazine compds. of formula I as inhibitors of protein and/or checkpoint kinases, methods of prepg. such compds., pharmaceutical compns. including one or more such compds., methods of prepg. pharmaceutical formulations including one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the protein or checkpoint kinases using such compds. or pharmaceutical compns. Compds. of formula I wherein R is H, halo, amino, (un)substituted alkyl, (un)substituted (hetero)aryl, (un)substituted (hetero)cycloalkyl, etc.; R1 is H, (un)substituted alkyl, (un)substituted (hetero)aryl(alkyl), (un)substituted cycloalkenyl, etc.; R2 and R3 are independently H, halo, amino, (un)substituted alkyl, (un)substituted (hetero)aryl, (un)substituted cycloalkyl, etc.; X is a covalent bond, CONH and derivs., SO2NH and derivs., NHCONH and derivs., CO2, OCO, OCONH and derivs., etc.; R4 is (un)substituted alkyl, (un)substituted CO2-alkyl, (un)substituted heterocyclyl, (un)substituted aryl and amine; and their pharmaceutically acceptable salts, solvates, esters and prodrugs thereof, are claimed. Example compd. II was prepd. by a multistep procedure (procedure given). All the invention compds. were evaluated for their protein kinase inhibitory activity (some data given).

In Czech

viz Anotace