Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors

GUZI, Timothy, Kamil PARUCH, Michael DWYER, Marc LABROLI and Kartik KEERTIKAR. Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors. 2007.

Basic information

Original name

Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors

Name in Czech

Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors

Authors

GUZI, Timothy, Kamil PARUCH, Michael DWYER, Marc LABROLI and Kartik KEERTIKAR

Edition

Number: US 2007/0281951 A1, Publisher: United States Patent and Trademark Office, Place of publication: USA, Owner's name: Schering-Plough, 2007

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Other information

Language

English

Type of outcome

Patent

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Science

Keywords (in Czech)

pyrazolopyrimidines; inhibitor; cyclin dependent kinase

Keywords in English

pyrazolopyrimidines; inhibitor; cyclin dependent kinase

Tags

Cyclin dependent kinase, inhibitor, pyrazolopyrimidines

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Abstract

V originále

The title compds. [I; R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I, alone or in combination with other therapeutic agent, is claimed.

In Czech

viz Anotace