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@misc{838051,
author = {Zhao, Lianyun and Curran, Patrick and Belanger, David and Hamann, Blake and Reddy, Panduranga and Paruch, Kamil and Guzi, Timothy and Dwyer, Michael and Siddiqui, Arshad and Tadikonda, Praveen},
keywords = {imidazopyrazine; protein kinase; inhibitor},
language = {eng},
title = {Imidazopyrazines as protein kinase inhibitors},
year = {2007}
}
TY - PAT
ID - 838051
AU - Zhao, Lianyun - Curran, Patrick - Belanger, David - Hamann, Blake - Reddy, Panduranga - Paruch, Kamil - Guzi, Timothy - Dwyer, Michael - Siddiqui, Arshad - Tadikonda, Praveen
PY - 2007
TI - Imidazopyrazines as protein kinase inhibitors
KW - imidazopyrazine
KW - protein kinase
KW - inhibitor
N2 - The title compds. I [R = H, cycloalkyl, heteroaryl, etc.; R1 = H, halo, aryl, etc.; R2 = H, halo, aryl, etc.; R3 = H, alkyl, cycloalkyl, etc.], useful as inhibitors of protein and/or checkpoint kinases, were prepd. A multi-step synthesis of II, starting from 2,3-dichloropyrazine, is given. Compds. I were tested against various kinases (data given for representative compds. I). This invention relates also to pharmaceutical compns. including one or more compds. I, methods of prepg. pharmaceutical formulations including one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the protein or checkpoint kinases using such compds. or pharmaceutical compns.
ER -
ZHAO, Lianyun, Patrick CURRAN, David BELANGER, Blake HAMANN, Panduranga REDDY, Kamil PARUCH, Timothy GUZI, Michael DWYER, Arshad SIDDIQUI a Praveen TADIKONDA. \textit{Imidazopyrazines as protein kinase inhibitors}. 2007. Patent. Číslo: WO 2007/058942 A2. Vydavatel: World Intellectual Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 8. 11. 2006. Datum přijetí: 24. 5. 2007.
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