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@misc{838056, author = {Guzi, Timothy and Paruch, Kamil and Dwyer, Michael and Parry, David and Zhao, Lianyun and Curran, Patrick and Belanger, David and Hamann, Blake and Reddy, Panduranga and Siddiqui, Arshad and Tadikonda, Praveen}, keywords = {kinases; cancer; inhibitor}, language = {eng}, title = {Methods for inhibiting protein kinases}, year = {2007} }
TY - PAT ID - 838056 AU - Guzi, Timothy - Paruch, Kamil - Dwyer, Michael - Parry, David - Zhao, Lianyun - Curran, Patrick - Belanger, David - Hamann, Blake - Reddy, Panduranga - Siddiqui, Arshad - Tadikonda, Praveen PY - 2007 TI - Methods for inhibiting protein kinases KW - kinases KW - cancer KW - inhibitor N2 - The invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim-1 kinase, and tyrosine kinase using imidazo[1,2-a]pyrazine compds. of formula I and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with protein kinases using such compds. Compds. of formula I wherein R is H, halo, (un)substituted (hetero)aryl, (un)substituted cycloalkyl, (un)substituted arylalkyl, (un)substituted heterocyclyl, etc.; R1 is H, halo, and alkyl; R2 is alkyl, (un)substituted (hetero)aryl(alkyl), alkenyl, alkynyl, etc.; R3 is H, (un)substituted (hetero)aryl(alkyl), (un)substituted heterocyclyl(alkyl), (un)substituted (hetero)cycloalkyl, etc.; and their pharmaceutically acceptable salts, solvates, esters, and prodrugs thereof are claimed. Example compd. II was prepd. by amination of 3-(1-methylpyrazol-4-yl)-7-methylsulfonylimidazo[1,2-a]pyrazine with 3-(methylsulfonyl)aniline. All the invention compds. were evaluated for their protein kinase inhibitory activity (data given). ER -
GUZI, Timothy, Kamil PARUCH, Michael DWYER, David PARRY, Lianyun ZHAO, Patrick CURRAN, David BELANGER, Blake HAMANN, Panduranga REDDY, Arshad SIDDIQUI and Praveen TADIKONDA. \textit{Methods for inhibiting protein kinases}. 2007.
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