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@misc{838066, author = {Guzi, Timothy and Paruch, Kamil and Dwyer, Michael}, keywords = {pyrazolopyrimidine; kinase; inhibitor}, language = {eng}, title = {Pyrazolopyrimidines as protein kinase inhibitors}, year = {2007} }
TY - PAT ID - 838066 AU - Guzi, Timothy - Paruch, Kamil - Dwyer, Michael PY - 2007 TI - Pyrazolopyrimidines as protein kinase inhibitors KW - pyrazolopyrimidine KW - kinase KW - inhibitor N2 - The title compds. I [X = NH, O, S; Ar = (un)substituted (hetero)aryl, fused (hetero)aryl; R1 = H, CF3, CN, etc.; R2 = H, CF3, CN, etc,; R3 = H, alkyl, alkenyl, etc.; R4 = H, OH, (un)substituted NH2], useful as inhibitors of protein and/or checkpoint kinases, were prepd. E.g., a 3-step synthesis of I [R1-R4 = H; X = O; Ar = 5-indolyl], starting from 1,3-dimethyluracil and 3-aminopyrazole, was given. This invention also relates to pharmaceutical compns. including one or more compds. I, methods of prepg. pharmaceutical formulations including one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the protein or checkpoint kinases using such compds. or pharmaceutical compns. ER -
GUZI, Timothy, Kamil PARUCH and Michael DWYER. \textit{Pyrazolopyrimidines as protein kinase inhibitors}. 2007.
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