GUZI, Timothy, Kamil PARUCH and Michael DWYER. Pyrazolopyrimidines as protein kinase inhibitors. 2007.
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Basic information
Original name Pyrazolopyrimidines as protein kinase inhibitors
Name in Czech Pyrazolopyrimidines as protein kinase inhibitors
Authors GUZI, Timothy, Kamil PARUCH and Michael DWYER.
Edition Number: US 2007/0082901 A1, Publisher: United States Patent and Trademark Office, Place of publication: USA, Owner's name: Schering-Plough, 2007.
Other information
Original language English
Type of outcome Patent
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Organization unit Faculty of Science
Keywords (in Czech) pyrazolopyrimidine; kinase; inhibitor
Keywords in English pyrazolopyrimidine; kinase; inhibitor
Tags inhibitor, Kinase, pyrazolopyrimidine
Changed by Changed by: doc. Mgr. Kamil Paruch, Ph.D., učo 108413. Changed: 25/6/2009 15:04.
Abstract
The title compds. I [X = NH, O, S; Ar = (un)substituted (hetero)aryl, fused (hetero)aryl; R1 = H, CF3, CN, etc.; R2 = H, CF3, CN, etc,; R3 = H, alkyl, alkenyl, etc.; R4 = H, OH, (un)substituted NH2], useful as inhibitors of protein and/or checkpoint kinases, were prepd. E.g., a 3-step synthesis of I [R1-R4 = H; X = O; Ar = 5-indolyl], starting from 1,3-dimethyluracil and 3-aminopyrazole, was given. This invention also relates to pharmaceutical compns. including one or more compds. I, methods of prepg. pharmaceutical formulations including one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the protein or checkpoint kinases using such compds. or pharmaceutical compns.
Abstract (in Czech)
viz Anotace
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