PARUCH, Kamil, Timothy GUZI, Michael DWYER and Carmen ALVAREZ. Pyrazolopyrimidines as protein kinase inhibitors. 2007.
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Basic information
Original name Pyrazolopyrimidines as protein kinase inhibitors
Name in Czech Pyrazolopyrimidines as protein kinase inhibitors
Authors PARUCH, Kamil, Timothy GUZI, Michael DWYER and Carmen ALVAREZ.
Edition Number: WO 2007/041712 A1, Publisher: World Intellectual Property Organization, Place of publication: USA, Owner's name: Schering-Plough, 2007.
Other information
Original language English
Type of outcome Patent
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Organization unit Faculty of Science
Keywords (in Czech) pyrazolopyrimidine; protein kinase; inhibitor
Keywords in English pyrazolopyrimidine; protein kinase; inhibitor
Tags inhibitor, protein kinase, pyrazolopyrimidine
Changed by Changed by: doc. Mgr. Kamil Paruch, Ph.D., učo 108413. Changed: 23/6/2009 16:47.
Abstract
The title compds. I [R2 = halo, CF3, CN, etc.; R3 = H, (un)substituted NH2, OH, etc.; R4 = CF3, CN, (un)substituted NH2, etc.], useful as inhibitors of protein and/or checkpoint kinases, were prepd. E.g., a multi-step synthesis of II, starting from N-tert-butoxycarbonylpiperidine-3-carboxylic acid, was given. II showed IC50 of 86 nM against CHK1 and IC50 of 989 nM against CDK2/cyclin A. This invention also relates to pharmaceutical compns. including one or more compds. I, methods of prepg. pharmaceutical formulations including one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the protein or checkpoint kinases using such compds. or pharmaceutical compns.
Abstract (in Czech)
viz Anotace
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