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@misc{838070, author = {Paruch, Kamil and Guzi, Timothy and Dwyer, Michael and Alvarez, Carmen}, keywords = {pyrazolopyrimidine; protein kinase; inhibitor}, language = {eng}, title = {Pyrazolopyrimidines as protein kinase inhibitors}, year = {2007} }
TY - PAT ID - 838070 AU - Paruch, Kamil - Guzi, Timothy - Dwyer, Michael - Alvarez, Carmen PY - 2007 TI - Pyrazolopyrimidines as protein kinase inhibitors KW - pyrazolopyrimidine KW - protein kinase KW - inhibitor N2 - The title compds. I [R2 = halo, CF3, CN, etc.; R3 = H, (un)substituted NH2, OH, etc.; R4 = CF3, CN, (un)substituted NH2, etc.], useful as inhibitors of protein and/or checkpoint kinases, were prepd. E.g., a multi-step synthesis of II, starting from N-tert-butoxycarbonylpiperidine-3-carboxylic acid, was given. II showed IC50 of 86 nM against CHK1 and IC50 of 989 nM against CDK2/cyclin A. This invention also relates to pharmaceutical compns. including one or more compds. I, methods of prepg. pharmaceutical formulations including one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the protein or checkpoint kinases using such compds. or pharmaceutical compns. ER -
PARUCH, Kamil, Timothy GUZI, Michael DWYER and Carmen ALVAREZ. \textit{Pyrazolopyrimidines as protein kinase inhibitors}. 2007.
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