Other formats:
BibTeX
LaTeX
RIS
@misc{838074, author = {Guzi, Timothy and Paruch, Kamil and Dwyer, Michael}, keywords = {pyrazolopyrimidine; cyclin dependent kinase; inhibitor}, language = {eng}, title = {Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors}, year = {2007} }
TY - PAT ID - 838074 AU - Guzi, Timothy - Paruch, Kamil - Dwyer, Michael PY - 2007 TI - Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors KW - pyrazolopyrimidine KW - cyclin dependent kinase KW - inhibitor N2 - Title compds. I [R2 = alkyl, alkynyl, alkynylalkyl, etc.; R3 = H, halo, alkyl, etc.; R4 = H, halo or alkyl; R5 = (un)substituted aryl which may optionally be fused with one or more heteroaryl], and their pharmaceutically acceptable salts, are prepd. and disclosed as inhibitors of cyclin dependent kinases (CDKs). Thus, e.g., II (R = H) was prepd. by substitution of III (prepn. given) with aniline, followed by deprotection. In in vitro kinase assays, II (R = pyrazo-1-yl) was found to possess an IC50 = 0.2 (.mu.M). Further disclosed are pharmaceutical compns. contg. I, methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. ER -
GUZI, Timothy, Kamil PARUCH and Michael DWYER. \textit{Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors}. 2007.
|