Other formats:
BibTeX
LaTeX
RIS
@misc{838078, author = {Guzi, Timothy and Paruch, Kamil and Dwyer, Michael and Labroli, Marc and Keertikar, Kartik}, keywords = {pyrazolopyrimidine; cyclin dependent kinase; inhibitor}, language = {eng}, title = {Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors}, year = {2007} }
TY - PAT ID - 838078 AU - Guzi, Timothy - Paruch, Kamil - Dwyer, Michael - Labroli, Marc - Keertikar, Kartik PY - 2007 TI - Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors KW - pyrazolopyrimidine KW - cyclin dependent kinase KW - inhibitor N2 - Title compds. I [R = H, alkyl, alkenyl, etc.; R2 = H, CF3, alkyl, heterocyclyl, etc.; R3 = H, halo, OH, SH, alkyl, etc.; R4 = H, halo or alkyl], and their pharmaceutically acceptable salts, are prepd. and disclosed as inhibitors of cyclin dependent kinases (CDKs). Thus, e.g., II was prepd. by amination of III (prepn. given) followed by deprotection. Methods for in vitro kinase assays are described, e.g., II was found to possess an IC50 value of 10 (.mu.M). Further disclosed are pharmaceutical compns. contg. one or more of I, methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. ER -
GUZI, Timothy, Kamil PARUCH, Michael DWYER, Marc LABROLI and Kartik KEERTIKAR. \textit{Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors}. 2007.
|