Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of
Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and
2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl
Derivatives of Imidazo[1,2-a]pyridines, and
Imidazo[1,5-a]pyrazines Compounds

P 2007

Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and 2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl Derivatives of Imidazo[1,2-a]pyridines, and Imidazo[1,5-a]pyrazines Compounds

MALLAMS, Alan, Vincent MADISON and Kamil PARUCH

Basic information

Original name

Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and 2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl Derivatives of Imidazo[1,2-a]pyridines, and Imidazo[1,5-a]pyrazines Compounds

Name in Czech

Authors

MALLAMS, Alan, Vincent MADISON and Kamil PARUCH

Edition

Number: WO 2007/032936 A2, Publisher: World Intellectula Property Organization, Place of publication: USA, Owner's name: Schering-Plough, 2007

Other information

Language

English

Type of outcome

Patent

Field of Study

10401 Organic chemistry

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Science

Keywords (in Czech)

cyclin dependent kinase; inhibitor

Keywords in English

cyclin dependent kinase; inhibitor

Abstract

ORIG CZ

V originále

The invention provides a class of bicyclic heterocyclic compds. of formulas I, II, and III as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Compds. of formulas I, II, and III wherein X is C or N; Y is CH, NH2, and CH2NH2; R1 is H, halo, NH2, (un)substituted alkyl, alkenyl, (hetero)aryl, CF3, etc.; R2 is H, halo, NH2 and derivs., CO2H and derivs., CONH2 and derivs., alkyl, alkenyl, alkynyl, cycloalkyl, (hetero)aryl, etc.; R3 is halo, CN, amino, alkylamino, cycloalkylamino, arylakylamino, hydroxyalkylamino, etc.; R4 is H, halo, CN and alkyl; are claimed. Example compd. IV was prepd. by cyanation of 5-bromo-6-phenyl-8-(pyridin-3-ylmethylamino)imidazo[1,5-a]pyrazine with zinc cyanide. All the invention compds. were evaluated for their CDK inhibitory activity.

In Czech

viz Anotace

Citovat

MALLAMS, Alan, Vincent MADISON and Kamil PARUCH. Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and 2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl Derivatives of Imidazo[1,2-a]pyridines, and Imidazo[1,5-a]pyrazines Compounds. 2007.

@misc{838344,
   author = {Mallams, Alan and Madison, Vincent and Paruch, Kamil},
   keywords = {cyclin dependent kinase; inhibitor},
   language = {eng},
   title = {Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and 2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl Derivatives of Imidazo[1,2-a]pyridines, and Imidazo[1,5-a]pyrazines Compounds},
   year = {2007}
}

TY  - PAT
ID  - 838344
AU  - Mallams, Alan - Madison, Vincent - Paruch, Kamil
PY  - 2007
TI  - Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and 2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl Derivatives of Imidazo[1,2-a]pyridines, and Imidazo[1,5-a]pyrazines Compounds
KW  - cyclin dependent kinase
KW  - inhibitor
N2  - The invention provides a class of bicyclic heterocyclic compds. of formulas I, II, and III as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Compds. of formulas I, II, and III wherein X is C or N; Y is CH, NH2, and CH2NH2; R1 is H, halo, NH2, (un)substituted alkyl, alkenyl, (hetero)aryl, CF3, etc.; R2 is H, halo, NH2 and derivs., CO2H and derivs., CONH2 and derivs., alkyl, alkenyl, alkynyl, cycloalkyl, (hetero)aryl, etc.; R3 is halo, CN, amino, alkylamino, cycloalkylamino, arylakylamino, hydroxyalkylamino, etc.; R4 is H, halo, CN and alkyl; are claimed. Example compd. IV was prepd. by cyanation of 5-bromo-6-phenyl-8-(pyridin-3-ylmethylamino)imidazo[1,5-a]pyrazine with zinc cyanide. All the invention compds. were evaluated for their CDK inhibitory activity.
ER  -

MALLAMS, Alan, Vincent MADISON and Kamil PARUCH. \textit{Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and 2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl Derivatives of Imidazo[1,2-a]pyridines, and Imidazo[1,5-a]pyrazines Compounds}. 2007.

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