GUZI, Timothy, Kamil PARUCH, Michael DWYER, Marc LABROLI and Kartik KEERTIKAR. Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors. 2006.
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Basic information
Original name Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors
Name in Czech Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors
Authors GUZI, Timothy, Kamil PARUCH, Michael DWYER, Marc LABROLI and Kartik KEERTIKAR.
Edition Number: US 2006128725 A1, Publisher: US Patent Office, Place of publication: USA, Owner's name: Schering-Plough, 2006.
Other information
Original language English
Type of outcome Patent
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Organization unit Faculty of Science
Keywords (in Czech) cancer; pyrazolopyrimidines; cyclin dependent kinase; inhibitor
Keywords in English cancer; pyrazolopyrimidines; cyclin dependent kinase; inhibitor
Tags cancer, Cyclin dependent kinase, inhibitor, pyrazolopyrimidines
Changed by Changed by: doc. Mgr. Kamil Paruch, Ph.D., učo 108413. Changed: 25/6/2009 08:39.
Abstract
The title compds. are substituted pyrazolo[1,5-a]pyrimidines [I; R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I is claimed.
Abstract (in Czech)
viz Anotace
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