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@misc{838347, author = {Guzi, Timothy and Paruch, Kamil and Dwyer, Michael and Labroli, Marc and Keertikar, Kartik}, keywords = {cancer; pyrazolopyrimidines; cyclin dependent kinase; inhibitor}, language = {eng}, title = {Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors}, year = {2006} }
TY - PAT ID - 838347 AU - Guzi, Timothy - Paruch, Kamil - Dwyer, Michael - Labroli, Marc - Keertikar, Kartik PY - 2006 TI - Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors KW - cancer KW - pyrazolopyrimidines KW - cyclin dependent kinase KW - inhibitor N2 - The title compds. are substituted pyrazolo[1,5-a]pyrimidines [I; R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I is claimed. ER -
GUZI, Timothy, Kamil PARUCH, Michael DWYER, Marc LABROLI and Kartik KEERTIKAR. \textit{Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors}. 2006.
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