GUZI, Timothy and Kamil PARUCH. Pyrazolotriazines as Kinase Inhibitors. 2005.
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Basic information
Original name Pyrazolotriazines as Kinase Inhibitors
Name in Czech Pyrazolotriazines as Kinase Inhibitors
Authors GUZI, Timothy (840 United States of America) and Kamil PARUCH (203 Czech Republic, guarantor).
Edition Number: US 2005/187219 A1, Publisher: United States Patent and Trademark Office, Place of publication: USA, Owner's name: Schering-Plough, 2005.
Other information
Original language English
Type of outcome Patent
Field of Study 10401 Organic chemistry
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/05:00035986
Organization unit Faculty of Science
Keywords (in Czech) kinase; pyrazolotriazine; inhibitor
Keywords in English kinase; pyrazolotriazine; inhibitor
Tags inhibitor, Kinase, pyrazolotriazine
Changed by Changed by: doc. Mgr. Kamil Paruch, Ph.D., učo 108413. Changed: 25/6/2009 15:07.
Abstract
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]triazine compds. (I, variables defined below) as inhibitors of kinases such as, for example, cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the kinases using such compds. or pharmaceutical compns. For I, R1 is H, optionally substituted alkyl, aryl, heteroaryl, heteroarylalkyl, arylalkyl, NR6R7, cycloalkyl and cycloalkylalkyl; R2 is alkyl, cycloalkyl, alkenyl, alkynyl, trifluoromethyl, OR7, SR7, hydroxyalkyl, haloalkyl, aryl, heteroaryl, halo, CN, formyl, nitro, alkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, or alkylene-N(R8R9) [where R8 and R9 represent H or alkyl, or R8 and R9 taken together with the nitrogen in -N(R8R9) form a five- to seven-membered heterocycle]; R3 is -NR4R5, substituted heterocycle, H, alkyl, alkylthio, aralkylthio, alkylsulfinyl, or aralkylsulfinyl; R4 is optionally substituted alkyl, cycloalkyl or heterocyclyl; R5 is H, alkyl, aryl, heteroaryl, arylalkyl, cycloalkyl, heterocyclyl, acyl or heteroarylalkyl; R6 is H, alkyl or aryl; R7 is H or alkyl.
Abstract (in Czech)
viz Anotace
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