P 2005

Pyrazolotriazines as Kinase Inhibitors

GUZI, Timothy and Kamil PARUCH

Basic information

Original name

Pyrazolotriazines as Kinase Inhibitors

Name in Czech

Pyrazolotriazines as Kinase Inhibitors

Authors

GUZI, Timothy (840 United States of America) and Kamil PARUCH (203 Czech Republic, guarantor)

Edition

Number: US 2005/187219 A1, Publisher: United States Patent and Trademark Office, Place of publication: USA, Owner's name: Schering-Plough, 2005

Other information

Language

English

Type of outcome

Patent

Field of Study

10401 Organic chemistry

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/05:00035986

Organization unit

Faculty of Science

Keywords (in Czech)

kinase; pyrazolotriazine; inhibitor

Keywords in English

kinase; pyrazolotriazine; inhibitor

Tags

Změněno: 25/6/2009 15:07, doc. Mgr. Kamil Paruch, Ph.D.

Abstract

ORIG CZ

V originále

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]triazine compds. (I, variables defined below) as inhibitors of kinases such as, for example, cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the kinases using such compds. or pharmaceutical compns. For I, R1 is H, optionally substituted alkyl, aryl, heteroaryl, heteroarylalkyl, arylalkyl, NR6R7, cycloalkyl and cycloalkylalkyl; R2 is alkyl, cycloalkyl, alkenyl, alkynyl, trifluoromethyl, OR7, SR7, hydroxyalkyl, haloalkyl, aryl, heteroaryl, halo, CN, formyl, nitro, alkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, or alkylene-N(R8R9) [where R8 and R9 represent H or alkyl, or R8 and R9 taken together with the nitrogen in -N(R8R9) form a five- to seven-membered heterocycle]; R3 is -NR4R5, substituted heterocycle, H, alkyl, alkylthio, aralkylthio, alkylsulfinyl, or aralkylsulfinyl; R4 is optionally substituted alkyl, cycloalkyl or heterocyclyl; R5 is H, alkyl, aryl, heteroaryl, arylalkyl, cycloalkyl, heterocyclyl, acyl or heteroarylalkyl; R6 is H, alkyl or aryl; R7 is H or alkyl.

In Czech

viz Anotace