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@misc{838370, author = {Guzi, Timothy and Paruch, Kamil}, keywords = {kinase; pyrazolotriazine; inhibitor}, language = {eng}, title = {Pyrazolotriazines as Kinase Inhibitors}, year = {2005} }
TY - PAT ID - 838370 AU - Guzi, Timothy - Paruch, Kamil PY - 2005 TI - Pyrazolotriazines as Kinase Inhibitors KW - kinase KW - pyrazolotriazine KW - inhibitor N2 - In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]triazine compds. (I, variables defined below) as inhibitors of kinases such as, for example, cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the kinases using such compds. or pharmaceutical compns. For I, R1 is H, optionally substituted alkyl, aryl, heteroaryl, heteroarylalkyl, arylalkyl, NR6R7, cycloalkyl and cycloalkylalkyl; R2 is alkyl, cycloalkyl, alkenyl, alkynyl, trifluoromethyl, OR7, SR7, hydroxyalkyl, haloalkyl, aryl, heteroaryl, halo, CN, formyl, nitro, alkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, or alkylene-N(R8R9) [where R8 and R9 represent H or alkyl, or R8 and R9 taken together with the nitrogen in -N(R8R9) form a five- to seven-membered heterocycle]; R3 is -NR4R5, substituted heterocycle, H, alkyl, alkylthio, aralkylthio, alkylsulfinyl, or aralkylsulfinyl; R4 is optionally substituted alkyl, cycloalkyl or heterocyclyl; R5 is H, alkyl, aryl, heteroaryl, arylalkyl, cycloalkyl, heterocyclyl, acyl or heteroarylalkyl; R6 is H, alkyl or aryl; R7 is H or alkyl. ER -
GUZI, Timothy and Kamil PARUCH. \textit{Pyrazolotriazines as Kinase Inhibitors}. 2005.
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